1,3-Cyclopentadiene, 1,2,3,4,5,5-hexachloro-

RTECS #

GY1225000

CAS #

77-47-4
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

272.75

Molecular Formula

C₅Cl₆

Synonyms

1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene
C-56
Graphlox
Hexachlorcyklopentadien (Czech)
Hexachloro-1,3-cyclopentadiene
Hexachlorocyclopentadiene
Hexachlorocyclopentadiene (ACGIH)
HRS 1655
NCI-C55607
Perchlorocyclopentadiene
RCRA waste number U130

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	20 mg/24H	moderate	85JCAE -,149,1986
eye /rabbit	100 mg/5M	severe	VELPB* #50101-2,1976
skin /guinea pig	20 mg	mild	AMIHAB 11,459,1955
skin /monkey	10 mg	severe	AMIHAB 11,459,1955
skin /rabbit	500 mg/4H	severe	VELPB* #50101-2,1976
skin /rabbit	500 µL/24H	severe	NTIS** OTS0537036

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	other cell types/hamster	27.5 µmol/L	MUREAV 608,28,2006

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rabbit	975 mg/kg (6-18D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 53,497,1980

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lowest published lethal concentration: 84 mg/m³/7H		VCVGH* -,551,1990
inhalation/Dog	Lowest published lethal concentration: 840 mg/m³/30M		VCVGH* -,551,1990
inhalation/guinea pig	Lowest published lethal concentration: 139 mg/m³/3H		VCVGH* -,551,1990
inhalation/guinea pig	Lowest published lethal concentration: 3200 ppb/7H		AMIHAB 11,459,1955
inhalation/mouse	Lowest published lethal concentration: 139 mg/m³/3H		VCVGH* -,551,1990
inhalation/mouse	Lowest published lethal concentration: 1500 ppb/7H		TXAPA9 53,497,1980
inhalation/rabbit	Lowest published lethal concentration: 1500 ppb/7H		TXAPA9 53,497,1980
inhalation/rabbit	Lowest published lethal concentration: 139 mg/m³/3H		VCVGH* -,551,1990
inhalation/rat	lethal concentration (50 percent kill): 23 mg/m³/2H		VCVGH* -,551,1990
inhalation/rat	Lowest published lethal concentration: 139 mg/m³/3H		VCVGH* -,551,1990
inhalation/rat	lethal concentration (50 percent kill): 1600 ppb/4H	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes	JTEHD6 9,743,1982
oral/mouse	lethal dose (50 percent kill): 505 mg/kg		JAFCAU 23,967,1975
oral/rabbit	lowest published lethal dose: 420 mg/kg		PCOC** -,586,1966
oral/rabbit	lethal dose (50 percent kill): 620 mg/kg	Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	ENTOX* -,517,2005
oral/rat	lethal dose (50 percent kill): 420 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Hypermotility, diarrhea	ENTOX* -,517,2005
oral/rat	lethal dose (50 percent kill): 200 mg/kg		VCVGH* -,552,1990
skin/rabbit	lowest published lethal dose: 300 mg/kg		VCVGH* -,552,1990
skin/rabbit	lethal dose (50 percent kill): 430 mg/kg		34ZIAG -,308,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 340 ppb/7H/6W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHAB 11,459,1955
inhalation/mouse	lowest published toxic concentration: 150 ppb/6H/13W- intermittent	Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOXID9 6,57,1986
inhalation/mouse	lowest published toxic concentration: 340 ppb/7H/6W- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHAB 11,459,1955
inhalation/rabbit	lowest published toxic concentration: 340 ppb/7H/6W- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHAB 11,459,1955
inhalation/rat	lowest published toxic concentration: 100 ppb/6H/30W- intermittent	Endocrine: Changes in spleen weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count	NTIS** OTS0539137
inhalation/rat	lowest published toxic concentration: 500 ppb/6H/2W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTEHD6 9,743,1982
inhalation/rat	lowest published toxic concentration: 400 ppb/6H/13W- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Changes in lung weight	NTPTR* NTP-TR-437,1994
oral/mouse	lowest published toxic dose: 2470 mg/kg/13W- intermittent	Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in bladder weight	JJATDK 4,75,1984
oral/rat	lowest published toxic dose: 2470 mg/kg/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JJATDK 4,75,1984

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.01 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		ENTOX* -,517,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		TOLED5 204,148,2011
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		MUTAEX 32,491,2017
TOXICOLOGY REVIEW		RTOPDW 54,294,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.01 ppm (0.11 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 0.01 ppm (0.11 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.01 ppm (0.1 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.01 ppm (0.11 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.01 ppm (0.1 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.01 ppm (0.1 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.01 ppm (0.1 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.01 ppm (0.1 mg/m³);short term exposure limit 0.03 ppm (0.3 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.01 ppm (0.11 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.01 ppm (0.1 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,01 ppm (0,11 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.01 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.01 ppm (0.1 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 1 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXACHLOROCYCLOPENTADIENE-air	10H time-weighted average 0.01 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code T0175; Number of Industries 2; Total Number of Facilities 61; Number of Occupations 14; Total Number of Employees Exposed 1427

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166670)
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
NIOSH Analytical Method, 1994: Hexachloro-1,3-cyclopentadiene, 2518
NTP Carcinogenesis studies (inhalation);no evidence:rat NTPTR* NTP-TR-437,1994
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health