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Registry of Toxic Effects of Chemical Substances (RTECS)

o-Cresol, 4,6-dinitro-

RTECS #

GO9625000

CAS #

534-52-1

Updated

September 2013

Molecular Weight

198.15

Molecular Formula

C7H6N2O5

Synonyms

2,4-Dinitro-6-methylphenol
2,4-Dinitro-o-cresol
2-Methyl-4,6-dinitrophenol
3,5-Dinitro-2-hydroxytoluene
4,6-Dinitrocresol
4,6-Dinitrokresol (Dutch)
4,6-Dinitro-o-cresol
4,6-Dinitro-o-cresolo (Italian)
4,6-Dinitro-o-kresol (Czech)
Antinonin
Antinonnin
Arborol
C.I. 10310
Capsine
Chemsect DNOC
Degrassan
Dekrysil
Detal
Detol
Dinitrocresol
Dinitrodendtroxal
Dinitrol
Dinitromethyl cyclohexyltrienol
Dinitro-o-cresol
Dinitro-o-cresol (ACGIH:OSHA)
Dinoc
Dinurania
Ditrosol
DNOC
DNOK (Czech)
Dwunitro-O-krezol (Polish)
Effusan
Effusan 3436
Elgetol
Elgetol 30
Elipol
ENT 154
Extrar
Hedolit
Hedolite
K III
K IV
Kresonite-E
Krezotol 50
LE dinitrocresol-4,6 (French)
Lipan
Neudorff DN 50
Nitrador
Nitrofan
Oranz viktoria (Czech)
Phenol, 2-methyl-4,6-dinitro- (9CI)
Prokarbol
Rafex
Rafex 35
Raphatox
RCRA waste number P047
Sandolin
Sandolin A
Selinon
Sinox
Winterwash
Zahlreiche bezeichnungen (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,678,1986
skin /rabbit 105 mg/9D- intermittent mildJIHTAB 30,10,1948

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat15 mg/kgMUREAV 321,219,1994
DNA repair/Other microorganisms10 mg/plateBIZNAT 95,463,1976
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)STBIBN 117,99,1987
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (-enzymatic activation step)AIDZAC 10,305,1982
mutation in microorganisms/Salmonella typhimurium100 µg/plate/48H (-enzymatic activation step)EMMUEG 47,95,2006
mutation in microorganisms/Salmonella typhimurium100 µg/plate/48HEMMUEG 47,95,2006
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster250 µmol/LATSUDG 4,59,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 75 mg/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)REPTED 22,501,2006
oral/rat 50 mg/kg (5D male)Related to Chronic Data: Changes in testicular weightREPTED 22,501,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 40 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 30(1-3),197,1965
inhalation/human lowest published toxic concentration: 1 mg/m3Brain and Coverings: Recordings from specific areas of CNS

Cardiac: Other changes

Gastrointestinal: Other changes
HYSAAV 30(1-3),197,1965
inhalation/mammal (species unspecified) lethal concentration (30 percent kill): 100 mg/m3GTPZAB 9(4),56,1965
intraperitoneal/guinea pig lethal dose (50 percent kill): 22500 µg/kgJPPMAB 6,619,1954
intraperitoneal/mouse lethal dose (50 percent kill): 19 mg/kgBCPCA6 18,1389,1969
intraperitoneal/rabbit lethal dose (50 percent kill): 23500 µg/kgJPPMAB 6,619,1954
intraperitoneal/rat lowest published lethal dose: 28 mg/kgTXAPA9 1,156,1959
intravenous/Dog lowest published lethal dose: 15 mg/kgAIPTAK 50,20,1935
intravenous/pigeon lowest published lethal dose: 7 mg/kgGastrointestinal: Nausea or vomiting

Lung, Thorax, or Respiration: Dyspnea
AIPTAK 50,20,1935
oral/cat lethal dose (50 percent kill): 50 mg/kgGTPZAB 9(4),56,1965
oral/domestic animal lethal dose (50 percent kill): 100 mg/kg85DPAN -,-,1971/1976
oral/duck lethal dose (50 percent kill): 383000 mg/kgHBPTO* 2,1229,2001
oral/guinea pig lethal dose (50 percent kill): 24600 µg/kgGISAAA 41(6),12,1976
oral/man lowest published toxic dose: 7500 µg/kg/7DBehavioral: Somnolence (general depressed activity)

Behavioral: Headache
CMEP** -,1,1956
oral/mouse lethal dose (50 percent kill): 21 mg/kgAMRL** TR-72-62,1972
oral/quail lethal dose (50 percent kill): 1040000 mg/kgHBPTO* 2,1229,2001
oral/rabbit lethal dose (50 percent kill): 24600 µg/kgGISAAA 41(6),12,1976
oral/rat lethal dose (50 percent kill): 7 mg/kgDEVEAA 26,69,1972
oral/rat lethal dose (50 percent kill): 40 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
FATOAO 47,90,1984
skin/child lowest published lethal dose: 500 mg/kgBehavioral: Coma

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
SMEZA5 17(1),52,1974
skin/guinea pig lowest published lethal dose: 500 mg/kgJIHTAB 30,10,1948
skin/rabbit lethal dose (50 percent kill): 1 gm/kgGTPZAB 9(4),56,1965
skin/rat lethal dose (50 percent kill): 200 mg/kgWRPCA2 9,119,1970
subcutaneous/rat lethal dose (50 percent kill): 25600 µg/kgJPPMAB 4,1062,1952
unreported route/man lowest published lethal dose: 29 mg/kg85DCAI 2,73,1970
unreported route/mouse lethal dose (50 percent kill): 40 mg/kgTGANAK 16(1),45,1982
unreported route/rat lethal dose (50 percent kill): 85 mg/kgGTPZAB 26(6),21,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 2 mg/m3/4H/4W- intermittentEndocrine: Hyperglycemia

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 30(2),34,1965
intraperitoneal/guinea pig lowest published toxic dose: 780 mg/kg/30D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
AMASA4 34,87,1977
oral/rat lowest published toxic dose: 45500 µg/kg/26W- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 41(6),12,1976

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg/m3 (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWFNSCA6 2,67,1973
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWREPTED 26,185,2008
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,175,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg/m3 (skin)DTLVS* 3,93,1971
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 mg/m3, Skin, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.2 mg/m3, short term exposure limit 0.8 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg/m3, skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,2 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 mg/m3, KZG-week 0.4 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DINITRO-o-CRESOL-air10H time-weighted average 0.2 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264321)
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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