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Registry of Toxic Effects of Chemical Substances (RTECS)

Aziridine, 2-methyl-

RTECS #

CM8050000

CAS #

75-55-8

Updated

September 2013

Molecular Weight

57.11

Molecular Formula

C3H7N

Synonyms

1,2-Propyleneimine
1,2-Propylenimine
2-Methylazacyclopropane
2-Methylaziridine
2-Methylethylenimine
Methylethylenimine
Propylene imine
Propylene imine (ACGIH:OSHA)
Propylenimine
RCRA waste number P067

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageintraperitoneal/mouse40 mg/kgMUREAV 467,83,2000
DNA Damagelung/hamster300 µmol/L/1HBBRCA9 72,732,1976
DNA repair/Escherichia coli2 µg/plateJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae100 ppmJJIND8 62,901,1979
host-mediated assaySalmonella typhimurium/mouse355 mg/kgJJIND8 62,911,1979
micronucleus testintraperitoneal/mouse10 mg/kgMUREAV 389,3,1997
morphological transformfibroblast/mouse80 µg/LJJIND8 67,1303,1981
morphological transformembryo/hamster1 mg/LJJIND8 67,1303,1981
morphological transformembryo/rat15 mg/LJJIND8 67,1303,1981
mutation in microorganisms/Schizosaccharomyces pombe5470 µmol/L (-enzymatic activation step)ADWMAX -,193,1962
mutation in microorganisms/Salmonella typhimurium3300 ng/plate (+/-enzymatic activation step)ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms/Escherichia coli10 µg/plate (+enzymatic activation step)ENMUDM 6(Suppl 2),1,1984
other mutation test systems/Escherichia coli80 nmol/tubeMUREAV 147,79,1985
specific locus testoral/Drosophila melanogaster1 mmol/LMUREAV 252,305,1991
Unscheduled DNA Synthesisliver/rat10 mg/LMUREAV 97,359,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1120 mg/kg/28W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors
NATUAS 230,460,1971
oral/rat toxic dose: 3920 mg/kg/27W- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Skin and Appendages: Tumors
JJIND8 67,75,1981
oral/rat toxic dose: 4129 mg/kg/58W- continuousTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
JJIND8 67,75,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 500 ppm/1HLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JIHTAB 30,2,1948
inhalation/mouse Lethal concentration: >2 gm/m3/10MNDRC** NDCrc-132,Feb,1942
inhalation/rat Lowest published lethal concentration: 500 ppm/4HJIHTAB 31,343,1949
intraperitoneal/mouse lethal dose (50 percent kill): 355 mg/kgJJIND8 62,911,1979
oral/rat lethal dose (50 percent kill): 19 mg/kgJIHTAB 30,63,1948
skin/guinea pig lethal dose (50 percent kill): 43 mL/kgJIHTAB 30,63,1948

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 ppm;short term exposure limit 0.4 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 9,61,1975
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1497,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 9,61,1975
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1497,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1497,1999
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 ppm (5 mg/m3) (skin)DTLVS* 3,218,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (4.7 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (4.8 mg/m3), Skin, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (5 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 2 ppm (4.7 mg/m3), skin, NOV2011
Occupational Exposure Limit-HUNGARYceiling concentration 5 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (5 mg/m3), carc, skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 2 ppm (4.7 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (5 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (5 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (4.7 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (4.7 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 2 ppm, JUN2003
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (5 mg/m3), carc 2, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.6 µg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2 ppm (5 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2 ppm (5 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2 ppm (5 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2 ppm (5 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE IMINE-air10H Carcinogen time-weighted average 2 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 08390; Number of Industries 1; Total Number of Facilities 5; Number of Occupations 2; Total Number of Employees Exposed 20

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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