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Registry of Toxic Effects of Chemical Substances (RTECS)

Adiponitrile

RTECS #

AV2625000

CAS #

111-69-3

Updated

September 2013

Molecular Weight

108.16

Molecular Formula

C6H8N2

Synonyms

1,4-Dicyanobutane
Adipic acid dinitrile
Adipic acid nitrile
Adipinsaeuredinitril (German)
Adiponitril (ACGIH)
Hexanedinitrile
Hexanedioic acid, dinitrile
Nitrile adipico (Italian)
Tetramethylene cyanide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mL mildHPV215 -,-,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 100 mg/m3 (22D prior to copulation)Reproductive: Other effects on femaleHPV215 -,-,2001
oral/rat 1120 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 7,33,1986
oral/rat 1400 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)DCTODJ 27,123,2004
oral/rat 1120 mg/kg (6-19D pregnant)Reproductive: Other effects on femaleHPV215 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1710 mg/m3/4HEar: Change in acuity

Lung, Thorax, or Respiration: Other changes
TOXID9 1,76,1981
inhalation/rat lethal concentration (50 percent kill): 1.71 gm/m3/4HDCTODJ 27,123,2004
inhalation/rat Lowest published lethal concentration: 0.83 gm/m3/4HEye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
DCTODJ 27,123,2004
inhalation/rat Lowest published lethal concentration: 0.83 gm/m3/4HGastrointestinal: Changes in structure or function of salivary glandsDCTODJ 27,123,2004
inhalation/rat lethal concentration (50 percent kill): 1710 mg/m3/4HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
HPV215 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 40 mg/kgNTIS** AD691-490
oral/cat lethal dose (50 percent kill): 25 mg/kgZAARAM 19,225,1969
oral/mouse lethal dose (50 percent kill): 172 mg/kgENTOX* -,49,2005
oral/rabbit lethal dose (50 percent kill): 22 mg/kgENTOX* -,49,2005
oral/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 27,123,2004
oral/rat lethal dose (50 percent kill): 155 mg/kgENTOX* -,49,2005
oral/rat lethal dose (50 percent kill): 138 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV215 -,-,2001
skin/rabbit lethal dose (50 percent kill): 2134 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
HPV215 -,-,2001
skin/rabbit lowest published lethal dose: 1 mg/kgZAARAM 19,225,1969
skin/rabbit lethal dose (50 percent kill): 2134 mg/kg/24HDCTODJ 27,123,2004
skin/rabbit lowest published lethal dose: 1260 mg/kg/24HBehavioral: Sleep

Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)
DCTODJ 27,123,2004
skin/rabbit lowest published lethal dose: 1260 mg/kg/24HGastrointestinal: Nausea or vomitingDCTODJ 27,123,2004
subcutaneous/guinea pig lethal dose (50 percent kill): 50 mg/kgENTOX* -,49,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 500 mg/m3/4W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
DCTODJ 27,123,2004
inhalation/rat lowest published toxic concentration: 500 mg/m3/4W- intermittentBlood: Changes in spleenDCTODJ 27,123,2004
inhalation/rat lowest published toxic concentration: 100 mg/m3/22D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainDCTODJ 27,123,2004
inhalation/rat lowest published toxic concentration: 493 mg/m3/6H/4W- intermittentBlood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 30,199,1990
inhalation/rat lowest published toxic concentration: 99 mg/m3/6H/13W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
JTEHD6 30,199,1990
inhalation/rat lowest published toxic concentration: 3028 µg/m3/5H/26W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GTPZAB 25(9),64,1981
inhalation/rat lowest published toxic concentration: 30 mg/m3/2W- intermittentLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
DCTODJ 27,123,2004
inhalation/rat lowest published toxic concentration: 100 mg/m3/2W- intermittentBlood: Other changesDCTODJ 27,123,2004
inhalation/rat lowest published toxic concentration: 300 mg/m3/2W- intermittentBlood: Changes in erythrocyte (RBC) countDCTODJ 27,123,2004
inhalation/rat lowest published toxic concentration: 99 mg/m3/13W- intermittentBlood: Other changes

Blood: Changes in erythrocyte (RBC) count
HPV215 -,-,2001
oral/Dog lowest published toxic dose: 350 mg/kg/244D- continuousGastrointestinal: Nausea or vomitingDCTODJ 27,123,2004
oral/rat lowest published toxic dose: 1120 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldDCTODJ 27,123,2004
oral/rat lowest published toxic dose: 2920 mg/kg/2Y- intermittentEndocrine: Adrenal cortex hypoplasia

Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV215 -,-,2001
oral/rat lowest published toxic dose: 1120 mg/kg/14D- intermittentCardiac: Pericarditis

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV215 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWDCTODJ 27,123,2004
TOXICOLOGY REVIEWENTOX* -,49,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (8.9 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (8.8 mg/m3), skin, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (8.8 mg/m3), skin, NOV2011
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (8.8 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 8.8 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ADIPONITRILE-air10H time-weighted average 4 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X4253; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 2; Total Number of Employees Exposed 478; Total Number of Female Employees Exposed 41

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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