Symptoms, Diagnosis, and Treatment


  • Most people infected with Heartland virus experience fever, fatigue (feeling tired), decreased appetite, headache, nausea, diarrhea, and muscle or joint pain. Many are hospitalized because of their symptoms.
  • Some people also have lower than normal counts of white blood cells (cells that help fight infections) and lower than normal counts of platelets (which help clot blood). Sometimes tests to check how well the liver is working (liver function tests) can show increased levels of liver enzymes.
  • Symptoms and signs of Heartland virus disease (Heartland) are often similar to those of other tickborne illnesses, such as ehrlichiosis or anaplasmosis.
  • It can take up to two weeks for symptoms to appear after an infected tick bite.


  • See your healthcare provider if you develop the symptoms described above.
  • Your healthcare provider can order tests to look for Heartland virus infection.
  • To learn more about testing, visit our Healthcare Providers page.


  • There are no vaccines or medications to prevent or treat infection with Heartland virus. Antibiotics do not treat viruses.
  • Healthcare providers might be able to provide medications and other care to help treat symptoms. Some patients may need to be hospitalized for intravenous fluids and treatment for pain, fever, or other related problems.