Since human cases of glanders are rare, there is limited information about antibiotic treatment in humans. Sulfadiazine has been found to be effective in experimental animals and in humans.

In addition, the bacterium that causes glanders is usually susceptible to:

  • Tetracyclines
  • Ciprofloxacin
  • Streptomycin
  • Novobiocin
  • Gentamicin
  • Imipenem
  • Ceftazidime
  • Sulfonamides

In 2010, HHS convened a workshop with internationally recognized leaders in the field of Burkholderia species (the species of germ that causes melioidosis, glanders and other related infections) and clinicians with expertise in treating Burkholderia. Workshop attendees recommended treatment regimens for and post-exposure prophylaxis for melioidosis and glanders. More details on the recommendations can be found in the summary, published in CDC’s Emerging Infectious Diseases journal.