Risk factors for amyotrophic lateral sclerosis: a regional U.S. case‐control study

Affiliates Angeline S. Andrew [1], Walter G. Bradley [2], Daniel Peipert [1], Tanya Butt [1], Kwadwo Amoako [1], Erik P. Pioro, PhD [3], Rup Tandan [4], John Novak [5], Adam Quick [6], K. Doug Pugar [7], Komal Sawlani MD [8], Bashar Katirji [8], Todd A. Hayes [9], Pamela Cazzolli [10], Jiang Gui [11],Paul Mehta [12], D. Kevin Horton [12], Elijah W. Stommel [1]


[1] Dartmouth-Hitchcock Medical Center
[2] University of Miami Miller School of Medicine
[3] Center for ALS and Related Disorders, Cleveland Clinic
[4] Larner College of Medicine, University of Vermont
[5] Ohio Health Physician Group
[6] Department of Neurology, Ohio State University Wexner Medical Center
[7] Dayton Center for Neurological Disorders
[8] Department of Neurology, University Hospital Cleveland Medical Center/Case Western Reserve University
[9] Riverhills Neuroscience
[10] ALS Care Project
[11] Department of Biomedical Data Science, Dartmouth College
[12] Centers for Disease Control and Prevention (CDC), Agency for Toxic Substances and Disease Registry (ATSDR)

Journal Muscle and Nerve
Summary The etiology of amyotrophic lateral sclerosis (ALS) is still largely uncharacterized. This study reports higher odds of receiving an ALS diagnosis for persons who reported head trauma, experiencing severe electrical burns, hobbies involving lead, and employment in mechanics, painting, or construction.
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