CDC Science Clips

Drug Safety

1. Methadone-related emergency department visits involving nonmedical use.
   Substance Abuse and Mental Health Services Administration (SAMHSA).
   The DAWN Report. 2012 2012.


2. Maternal use of bupropion and risk for congenital heart defects
   Alwan S, Reefhuis J, Botto LD, Rasmussen SA, Correa A, Friedman JM.
   Am J Obstet Gynecol. 2010 Jul;203(1):52 e1-6.


3. Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur
   Black DM, Kelly MP, Genant HK, Palermo L, Eastell R, Bucci-Rechtweg C, Cauley J, et al.
   N Engl J Med. 2010 May 13;362(19):1761-71.


4. Pediatric adverse drug events in the outpatient setting: an 11-year national analysis
   Bourgeois FT, Mandl KD, Valim C, Shannon MW.
   Pediatrics. 2009 Oct;124(4):e744-50.


5. Medicare part D's exclusion of benzodiazepines and fracture risk in nursing homes
   Briesacher BA, Soumerai SB, Field TS, Fouayzi H, Gurwitz JH.
   Arch Intern Med. 2010 Apr 26;170(8):693-8.


6. Maternal treatment with opioid analgesics and risk for birth defects
   Broussard CS, Rasmussen SA, Reefhuis J, Friedman JM, Jann MW, Riehle-Colarusso T, Honein MA.
   Am J Obstet Gynecol. 2011 Feb 21.


7. The last mile: taking the final steps in preventing pediatric pharmaceutical poisonings
   Budnitz DS, Lovegrove MC.
   J Pediatr. 2011 Nov 5.


8. Emergency department visits for overdoses of acetaminophen-containing products
   Budnitz DS, Lovegrove MC, Crosby AE.
   Am J Prev Med. 2011 Jun;40(6):585-92.


9. Emergency hospitalizations for adverse drug events in older Americans
   Budnitz DS, Lovegrove MC, Shehab N, Richards CL.
   N Engl J Med. 2011 Nov 24;365(21):2002-12.


10. Preventing medication overdoses in young children: an opportunity for harm elimination
    Budnitz DS, Salis S.
    Pediatrics. 2011 May 9.


11. Age and gender trends in long-term opioid analgesic use for noncancer pain
    Campbell CI, Weisner C, Leresche L, Ray GT, Saunders K, Sullivan MD, Banta-Green CJ, et al.
    Am J Public Health. 2010 Dec;100(12):2541-7.


12. Levamisole: a dangerous new cocaine adulterant
    Chang A, Osterloh J, Thomas J.
    Clin Pharmacol Ther. 2010 Sep;88(3):408-11.


13. Increased risk of stroke associated with nonsteroidal anti-inflammatory drugs. A nationwide case-crossover study
    Chang CH, Shau WY, Kuo CW, Chen ST, Lai MS.
    Stroke. 2010 Jul 29.


14. Clinical experience with intravenous zanamivir under an emergency investigational new drug program in the United States
    Chan-Tack KM, Gao A, Himaya AC, Thompson EG, Singer ME, Uyeki TM, Birnkrant DB.
    J Infect Dis. 2013 Jan 1;207(1):196-8.


15. Clarification about hazardous drugs
    Connor TH, Mackenzie BA, Debord DG.
    Am J Health Syst Pharm. 2012 Nov 15;69(22):1949-50.


16. Putting risk into perspective: the US medical eligibility criteria for contraceptive use
    Curtis KM, Tepper NK, Marchbanks PA.
    Rev Endocr Metab Disord. 2011 May 5.


17. Exposure to hazardous drugs in healthcare: an issue that will not go away
    Davis J, McLauchlan R, Connor TH.
    J Oncol Pharm Pract. 2011 Mar;17(1):9-13.


18. Safety and pharmacokinetics of escalating daily doses of the antituberculosis drug rifapentine in healthy volunteers
    Dooley KE, Bliven-Sizemore EE, Weiner M, Lu Y, Nuermberger EL, Hubbard WC, Fuchs EJ, Melia MT, Burman WJ, Dorman SE.
    Clin Pharmacol Ther. 2012 Apr 4.


19. Opioid prescriptions for chronic pain and overdose: a cohort study
    Dunn KM, Saunders KW, Rutter CM, Banta-Green CJ, Merrill JO, Sullivan MD, Weisner CM, et al.
    Ann Intern Med. 2010 Jan 19;152(2):85-92.


20. An analysis of heavy utilizers of opioids for chronic noncancer pain in the TROUP study
    Edlund MJ, Martin BC, Fan MY, Braden JB, Devries A, Sullivan MD.
    J Pain Symptom Manage. 2010 Aug;40(2):279-89.


21. Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study
    Fischer HD, Juurlink DN, Mamdani MM, Kopp A, Laupacis A.
    Arch Intern Med. 2010 Apr 12;170(7):617-21.


22. A modeling and simulation approach to characterize methadone QT prolongation using pooled data from five clinical trials in MMT patients
    Florian J, Garnett CE, Nallani SC, Rappaport BA, Throckmorton DC.
    Clin Pharmacol Ther. 2012 Apr;91(4):666-72.


23. 20 microg versus >20 microg estrogen combined oral contraceptives for contraception
    Gallo MF, Nanda K, Grimes DA, Lopez LM, Schulz KF.
    Cochrane Database Syst Rev. 2011 ;1:CD003989.


24. Trends in opioid use and dosing among socio-economically disadvantaged patients
    Gomes T, Juurlink D, Dhalla I, Mailis-Gagnon A, Paterson J, Mamdani M.
    Open Med. 2011 Feb;5(1).


25. Henoch-Scholein purpura and polysaccharide meningococcal vaccine
    Goodman MJ, Nordin JD, Belongia EA, Mullooly JP, Baggs J.
    Pediatrics. 2010 Aug;126(2):e325-9.


26. FDA on rosiglitazone: more on advisory committee decision
    Graham DJ, Gelperin K.
    BMJ. 2010 Sep 11;341:c4868.


27. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone
    Graham DJ, Ouellet-Hellstrom R, MaCurdy TE, Ali F, Sholley C, Worrall C, Kelman JA.
    JAMA. 2010 Jul 28;304(4):411-8.


28. Risk of adverse events following oseltamivir treatment in influenza outpatients, Vaccine Safety Datalink Project, 2007-2010
    Greene SK, Li L, Shay DK, Fry AM, Lee GM, Jacobsen SJ, Baxter R, Irving SA, Jackson ML, Naleway AL, Nordin JD, Narwaney KJ, Lieu TA.
    Pharmacoepidemiol Drug Saf. 2013 Apr;22(4):335-44.


29. Randomized trial of clinical safety of daily oral tenofovir disoproxil fumarate (TDF) among HIV-uninfected men who have sex with men (MSM) in the United States
    Grohskopf LA, Chillag KL, Gvetadze R, Liu AY, Thompson M, Mayer KH, Collins BM, Pathak SR, O'Hara B, Ackers ML, Rose CE, Grant RM, Paxton LA, Buchbinder SP.
    J Acquir Immune Defic Syndr. 2013 Mar 5.


30. Prescription drug use continues to increase: U.S. prescription drug data for 2007-2008
    Gu Q, Dillon CF, Burt VL.
    NCHS Data Brief. 2010 Sep(42):1-8.


31. Medications as a potential source of exposure to phthalates among women of childbearing age
    Hernandez-Diaz S, Su YC, Mitchell AA, Kelley KE, Calafat AM, Hauser R.
    Reprod Toxicol. 2013 Jan 18;37C:1-5.


32. Death due to community-associated Clostridium difficile in a woman receiving prolonged antibiotic therapy for suspected Lyme Disease
    Holzbauer SM, Kemperman MM, Lynfield R.
    Clin Infect Dis. 2010 Aug 1;51(3):369-70.


33. Influenza vaccination and vitamin K antagonist treatment: a placebo-controlled, randomized, double-blind crossover study
    Iorio A, Basileo M, Marcucci M, Guercini F, Camilloni B, Paccamiccio E, Vecchioli M, et al.
    Arch Intern Med. 2010 Apr 12;170(7):609-16.


34. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial
    Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, Cohen RM, Cuddihy R, et al.
    Lancet. 2010 Aug 7;376(9739):419-30.


35. Methadone: a review of drug-drug and pathophysiological interactions
    Kapur BM, Hutson JR, Chibber T, Luk A, Selby P.
    Crit Rev Clin Lab Sci. 2011 Jul-Aug;48(4):171-95.


36. Usefulness of prescription monitoring programs for surveillance--analysis of Schedule II opioid prescription data in Massachusetts, 1996-2006
    Katz N, Panas L, Kim M, Audet AD, Bilansky A, Eadie J, Kreiner P, et al.
    Pharmacoepidemiol Drug Saf. 2010 Feb;19(2):115-23.


37. Antiretroviral drug use during pregnancy and risk of premature delivery: is there a connection?
    Kourtis AP.
    J Infect Dis. 2010 Apr 1;201(7):978-80.


38. Does maternal use of tenofovir during pregnancy affect growth of HIV-exposed uninfected infants?
    Kuhn L, Bulterys M.
    AIDS. 2012 Jun 1;26(9):1167-9.


39. Inappropriate medication in home health care
    Lau DT, Dwyer LL.
    J Gen Intern Med. 2012 May;27(5):490; author reply 491.


40. The role of advice in medication administration errors in the pediatric ambulatory setting
    Lemer C, Bates DW, Yoon C, Keohane C, Fitzmaurice G, Kaushal R.
    J Patient Saf. 2009 Sep;5(3):168-75.


41. Opioid prescribing in emergency departments: the prevalence of potentially inappropriate prescribing and misuse
    Logan J, Liu Y, Paulozzi L, Zhang K, Jones C.
    Med Care. 2013 Apr 29.


42. Emergency department visits for antiviral adverse events during the 2009 H1N1 influenza pandemic
    Lovegrove MC, Shehab N, Hales CM, Poneleit K, Crane E, Budnitz DS.
    Public Health Rep. 2011 May-Jun;126(3):312-7.


43. The methadone epidemic: methadone-related deaths on the rise in Vermont
    Madden ME, Shapiro SL.
    Am J Forensic Med Pathol. 2011 Jun;32(2):131-5.


44. Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States
    Manthripragada AD, Zhou EH, Budnitz DS, Lovegrove MC, Willy ME.
    Pharmacoepidemiol Drug Saf. 2011 Aug;20(8):819-26.


45. Oral contraceptive formulation and risk of breast cancer
    Marchbanks PA, Curtis KM, Mandel MG, Wilson HG, Jeng G, Folger SG, McDonald JA, Daling JR, Bernstein L, Malone KE, Wingo PA, Simon MS, Norman SA, Strom BL, Ursin G, Weiss LK, Burkman RT, Spirtas R.
    Contraception. 2011 Sep 28.


46. Use of topiramate in pregnancy and risk of oral clefts
    Margulis AV, Mitchell AA, Gilboa SM, Werler MM, Mittleman MA, Glynn RJ, Hernandez-Diaz S.
    Am J Obstet Gynecol. 2012 Nov;207(5):405 e1-7.


47. Improving drug safety surveillance: lessons from rosiglitazone
    Masoudi FA.
    Circ Cardiovasc Qual Outcomes. 2010 Sep 1;3(5):444-6.


48. *Indicators of buprenorphine and methadone use and abuse: what do we know?
    Maxwell JC, McCance-Katz EF.
    Am J Addict. 2010 Jan-Feb;19(1):73-88.


49. Therapeutic errors among children in the community setting: nature, causes and outcomes
    Mc DT, Robinson J, MacLeod D, MacBean CE, Braitberg G.
    J Paediatr Child Health. 2009 May;45(5):304-9.


50. Clinical characteristics of veterans prescribed high doses of opioid medications for chronic non-cancer pain
    Morasco BJ, Duckart JP, Carr TP, Deyo RA, Dobscha SK.
    Pain. 2010 Dec;151(3):625-32.


51. Management of prescription and nonprescription drug use during pregnancy
    Morgan MA, Cragan JD, Goldenberg RL, Rasmussen SA, Schulkin J.
    J Matern Fetal Neonatal Med. 2010 Aug;23(8):813-9.


52. Obstetrician-gynaecologist knowledge of and access to information about the risks of medication use during pregnancy
    Morgan MA, Cragan JD, Goldenberg RL, Rasmussen SA, Schulkin J.
    J Matern Fetal Neonatal Med. 2010 Oct;23(10):1143-50.


53. Antimicrobial and antimotility agent use in persons with Shiga toxin-producing Escherichia coli O157 infection in FoodNet sites
    Nelson JM, Griffin PM, Jones TF, Smith KE, Scallan E.
    Clin Infect Dis. 2011 May;52(9):1130-2.


54. Impact of poor-quality medicines in the 'developing' world
    Newton PN, Green MD, Fernandez FM.
    Trends Pharmacol Sci. 2010 Mar;31(3):99-101.


55. Hormone therapy and fatal breast cancer
    Norman SA, Weber AL, Localio AR, Marchbanks PA, Ursin G, Strom BL, Weiss LK, Burkman RT, Bernstein L, Deapen DM, Folger SG, Simon MS, Nadel MR.
    Pharmacoepidemiol Drug Saf. 2010 May;19(5):440-7.


56. A flood of opioids, a rising tide of deaths
    Okie S.
    N Engl J Med. 2010 Nov 18;363(21):1981-5.


57. Prescription drug monitoring programs and death rates from drug overdose
    Paulozzi LJ, Kilbourne EM, Desai HA.
    Pain Med. 2011 Feb 18.


58. A national epidemic of unintentional prescription opioid overdose deaths: how physicians can help control it
    Paulozzi LJ, Weisler RH, Patkar AA.
    J Clin Psychiatry. 2011 Apr 19.


59. Adverse antiepileptic drug effects in new-onset seizures: a case-control study
    Perucca P, Jacoby A, Marson AG, Baker GA, Lane S, Benn EK, Thurman DJ, Hauser WA, Gilliam FG, Hesdorffer DC.
    Neurology. 2011 Jan 18;76(3):273-9.


60. Nevirapine-associated hepatotoxicity and rash among HIV-infected pregnant women in Kenya
    Peters PJ, Polle N, Zeh C, Masaba R, Borkowf CB, Oyaro B, Omolo P, Ogindo P, Ndivo R, Angira F, Lando R, Fowler MG, Weidle PJ, Thomas TK.
    J Int Assoc Physicians AIDS Care (Chic). 2012 Mar-Apr;11(2):142-9.


61. Safe lists for medications in pregnancy: inadequate evidence base and inconsistent guidance from Web-based information, 2011
    Peters SL, Lind JN, Humphrey JR, Friedman JM, Honein MA, Tassinari MS, Moore CA, Mathis LL, Broussard CS.
    Pharmacoepidemiol Drug Saf. 2013 Jan 29.


62. Increase in unintentional medication overdose deaths Oklahoma, 1994-2006
    Piercefield E, Archer P, Kemp P, Mallonee S.
    Am J Prev Med. 2010 Oct;39(4):357-63.


63. Balancing hypoglycemia and glycemic control: a public health approach for insulin safety
    Pogach L, Aron D.
    JAMA. 2010 May 26;303(20):2076-7.


64. If not now, when? Seizing the moment for antibiotic stewardship
    Pollack LA, Gould CV, Srinivasan A.
    Infect Control Hosp Epidemiol. 2013 Feb;34(2):117-8.


65. Use of clomiphene citrate and birth defects, National Birth Defects Prevention Study, 1997-2005
    Reefhuis J, Honein MA, Schieve LA, Rasmussen SA.
    Hum Reprod. 2010 Nov 26.


66. Increasing deaths involving oxycodone, Victoria, Australia, 2000-09
    Rintoul AC, Dobbin MD, Drummer OH, Ozanne-Smith J.
    Inj Prev. 2010 Jan 7.


67. The Ribavirin Pregnancy Registry: findings after 5 years of enrollment, 2003-2009
    Roberts SS, Miller RK, Jones JK, Lindsay KL, Greene MF, Maddrey WC, Williams IT, Liu J, Spiegel RJ.
    Birth Defects Res A Clin Mol Teratol. 2010 Jul;88(7):551-9.


68. Utah clinical guidelines on prescribing opioids for treatment of pain
    Rolfs RT, Johnson E, Williams NJ, Sundwall DN.
    J Pain Palliat Care Pharmacother. 2010 Sep;24(3):219-35.


69. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial
    Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC.
    JAMA. 2010 May 12;303(18):1815-22.


70. *Oral methadone for chronic noncancer pain: a systematic literature review of reasons for administration, prescription patterns, effectiveness, and side effects
    Sandoval JA, Furlan AD, Mailis-Gagnon A.
    Clin J Pain. 2005 Nov-Dec;21(6):503-12.


71. Monitoring for tuberculosis drug hepatotoxicity: moving from opinion to evidence
    Saukkonen JJ, Powell K, Jereb JA.
    Am J Respir Crit Care Med. 2012 Mar 15;185(6):598-9.


72. Diethylene glycol in health products sold over-the-counter and imported from Asian countries
    Schier JG, Barr DB, Li Z, Wolkin AF, Baker SE, Lewis LS, McGeehin MA.
    J Med Toxicol. 2010 Oct 7.


73. Reduction in surface contamination with antineoplastic drugs in 22 hospital pharmacies in the US following implementation of a closed-system drug transfer device
    Sessink PJ, Connor TH, Jorgenson JA, Tyler TG.
    J Oncol Pharm Pract. 2011 Mar;17(1):39-48.


74. Time to change the paradigm--from "potentially inappropriate" to real patient harms
    Shehab N, Budnitz DS.
    Arch Intern Med. 2011 Mar 14;171(5):473-4.


75. National estimates of emergency department visits for hemorrhage-related adverse events from clopidogrel plus aspirin and from warfarin
    Shehab N, Sperling LS, Kegler SR, Budnitz DS.
    Arch Intern Med. 2010 Nov 22;170(21):1926-33.


76. Impact of thiazolidinedione safety warnings on medication use patterns and glycemic control among veterans with diabetes mellitus
    Shi L, Zhao Y, Szymanski K, Yau L, Fonseca V.
    J Diabetes Complications. 2010 Aug 11.


77. A population-based cohort study on chronic pain: the role of opioids
    Sjogren P, Gronbaek M, Peuckmann V, Ekholm O.
    Clin J Pain. 2010 Nov-Dec;26(9):763-9.


78. Fungal infections associated with contaminated methylprednisolone injections - preliminary report
    Smith RM, Schaefer MK, Kainer MA, Wise M, Finks J, Duwve J, Fontaine E, Chu A, Carothers B, Reilly A, Fiedler J, Wiese AD, Feaster C, Gibson L, Griese S, Purfield A, Cleveland AA, Benedict K, Harris JR, Brandt ME, Blau D, Jernigan J, Weber JT, Park BJ.
    N Engl J Med. 2012 Dec 19.


79. Antipsychotic and benzodiazepine use among nursing home residents: findings from the 2004 National Nursing Home Survey
    Stevenson DG, Decker SL, Dwyer LL, Huskamp HA, Grabowski DC, Metzger ED, Mitchell SL.
    Am J Geriatr Psychiatry. 2010 Jun 22.


80. Risks for possible and probable opioid misuse among recipients of chronic opioid therapy in commercial and medicaid insurance plans: the TROUP study
    Sullivan MD, Edlund MJ, Fan MY, Devries A, Brennan Braden J, Martin BC.
    Pain. 2010 Aug;150(2):332-9.


81. Antimicrobial ointments and methicilllin-resistant Staphylococcus aureus USA 300
    Suzuki M, Yamada K, Nagao M, Aoki E, Matsumoto M, Hirayama T, Yamamoto H, Hiramatsu R, Ichiyama S.
    Emerg Infect Dis. 2011 Oct.


82. Safety of contraceptive use among women with peripartum cardiomyopathy: a systematic review
    Tepper NK, Paulen ME, Marchbanks PA, Curtis KM.
    Contraception. 2010 Jul;82(1):95-101.


83. The association of statin use with peripheral neuropathy in the US population 40 years of age or older
    Tierney EF, Thurman DJ, Beckles GL, Cadwell BL.
    J Diabetes. 2012 Nov 1.


84. Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control study
    Trifiro G, Gambassi G, Sen EF, Caputi AP, Bagnardi V, Brea J, Sturkenboom MC.
    Ann Intern Med. 2010 Apr 6;152(7):418-25, W139-40.


85. Levothyroxine dose and risk of fractures in older adults: nested case-control study
    Turner M, Camacho X, Fischer H, Austin P, Anderson G, Rochon P, Liscombe L.
    BMJ. 2011 ;342(d2238).


86. Severe injury or death in young children from therapeutic errors: a summary of 238 cases from the American Association of Poison Control Centers
    Tzimenatos L, Bond GR.
    Clin Toxicol (Phila). 2009 Apr;47(4):348-54.


87. An analysis of the root causes for opioid-related overdose deaths in the United States
    Webster LR, Cochella S, Dasgupta N, Fakata KL, Fine PG, Fishman SM, Grey T, et al.
    Pain Med. 2011 Jun;12 Suppl 2:S26-35.


88. The source of methadone in overdose deaths in Western Virginia in 2004
    Weimer MB, Korthuis PT, Behonick GS, Wunsch MJ.
    J Addict Med. 2011 Sep;5(3):188-202.


89. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial
    Wilkens P, Scheel IB, Grundnes O, Hellum C, Storheim K.
    JAMA. 2010 Jul 7;304(1):45-52.


90. Thrombocytopenia after vaccination: case reports to the US Vaccine Adverse Event Reporting System, 1990-2008
    Woo EJ, Wise RP, Menschik D, Shadomy SV, Iskander J, Beeler J, Varricchio F, Ball R.
    Vaccine. 2011 Feb 1;29(6):1319-23.


91. Parents' medication administration errors: role of dosing instruments and health literacy
    Yin HS, Mendelsohn AL, Wolf MS, Parker RM, Fierman A, van Schaick L, Bazan IS, et al.
    Arch Pediatr Adolesc Med. 2010 Feb;164(2):181-6.


92. Effects of statins on serum inflammatory markers: the U.S. National Health and Nutrition Examination Survey 1999-2004
    Yoon SS, Dillon CF, Carroll M, Illoh K, Ostchega Y.
    J Atheroscler Thromb. 2010 Aug 25.


93. Peramivir use for treatment of hospitalized patients with influenza A(H1N1)pdm09 under Emergency Use Authorization, October 2009 - June 2010
    Yu Y, Garg S, Yu PA, Kim HJ, Patel A, Merlin T, Redd S, Uyeki TM.
    Clin Infect Dis. 2012 Apr 5.


94. Contraceptive use among women with inflammatory bowel disease: A systematic review
    Zapata LB, Paulen ME, Cansino C, Marchbanks PA, Curtis KM.
    Contraception. 2010 Jul;82(1):72-85.


95. Paraplegia and paraparesis from intrathecal methotrexate and cytarabine contaminated with trace amounts of vincristine in China during 2007
    Zeng G, Ma H, Wang X, Yan H, Wan X, Jiang B, Fontaine RE, Wu Z, Lin S, Ruan F, Liu H.
    J Clin Oncol. 2011 Mar 21.


96. Severe hypoglycemia and risks of vascular events and death
    Zoungas S, Patel A, Chalmers J, de Galan BE, Li Q, Billot L, Woodward M, et al.
    N Engl J Med. 2010 Oct 7;363(15):1410-8.