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Feature Articles

Folic Acid Benefits
Learn how folic acid can prevent some birth defects.
(Published: January 6, 2014)

Pop Quiz!
How much do you know about Folic Acid? Take our quiz and find out.
(Published: January 7, 2013)

The Importance of Folic Acid
Read Anifa's story and find out what CDC is doing to help.
(Published: May 7, 2012)

Lack of Vitamins Containing Folic Acid and Diabetes-Associated Birth Defects 
The American Journal of Obstetrics and Gynecology has published a new CDC study: “Lack of Periconceptional Vitamins or Supplements That Contain Folic Acid and Diabetes Mellitus-Associated Birth Defects”.
(Published: March 13, 2012)

Scientific Articles

* Articles are listed in order of date published

AritclesFortification of corn masa flour with folic acid in the United States: an overview of the evidence
Ann N Y Acad Sci. 2014;1312:8-14.
Hamner HC, Tinker SC.
[Read Summary]

Modeling fortification of corn masa flour with folic acid: the potential impact on exceeding the tolerable upper intake level for folic acid, NHANES 2001-2008
Food & Nutrition Research 2013;57:19146.
Hamner HC, Tinker SC, Berry RJ, Mulinare J.
[Read Summary]

Modeling fortification of corn masa flour with folic acid and the potential impact on Mexican-American women with lower acculturation
Public Health Nutr. 2013;16(5):912-21.
Hamner HC, Tinker SC, Flores AL, Mulinare J, Weakland AP, Dowling NF.
[Read Summary]

Folate-related gene variants in Irish families affected by neural tube defects
Front Genet.2013; 4:223.
Fisk Green R, Byrne J, Crider KS, Gallagher M, Koontz D, Berry RJ.
[Read Summary]

Preconception folic acid supplementation and risk for chromosome 21 nondisjunction:  A report from the National Down Syndrome Project
American Journal of Medical Genetics Part A. 2013;161(3):438-44.
Hollis ND, Allen EG, Oliver TR, Tinker SW, Druschel C, Hobbs CA, O’Leary LA, Romitti PA, Royle MH, Torfs CP, Freeman SB, Sherman SL, Bean LJH.
[Read Summary]

The impact of folic acid intake on the association among diabetes mellitus, obesity, and spina bifida
Am J Obstet Gynecol. 2013; 209:239.e1-8.
Parker SE, Yazdy MM, Tinker SC, Mitchell AA, Werler MM.
[Read Summary]

Neural tube defects in Latin America and the impact of fortification: a literature review
Public Health Nutr.2013; 6:1-14.
Rosenthal J, Casas J, Taren D, Alverson CJ, Flores A, Frias J.
[Read Summary]

Estimate of the potential impact of folic acid fortification of corn masa flour on the prevention of neural tube defects
Birth Defects Res A Clin Mol Teratol. 2013;97(10):649-57.
Tinker SC, Devine O, Mai C, Hamner HC, Reefhuis J, Gilboa SM, Dowling NF, Honein MA.
[Read Summary]

Folic Acid Intake Among U.S. Women Aged 15-44 Years, National Health and Nutrition Examination Survey, 2003-2006
American Journal of Preventive Medicine. March 2010. [Epub ahead of print]
Tinker SC, Cogswell ME, Devine O, Berry RJ.
[Read Summary]

Predicted Contribution of Folic Acid Fortification of Corn Masa Flour to the Usual Folic Acid Intake for the US Population: National Health and Nutrition Examination Survey 2001-2004
The American Journal of Clinical Nutrition; January 2009; 89(1):305-15
Hamner HC, Mulinare J, Cogswell ME, Flores AL, Boyle CA, Prue CE, Wang CY, Carriquiry AL, Devine O.
[Read summary ]

Trends in the Postfortification Prevalence of Spina Bifida and Anencephaly in the United States
Birth Defects Research (Part A), Clinical and Molecular Teratology; 2008; 82:527-532
Boulet SL, Yang QH, Mai C, Kirby RS, Collins JS, Robbins JM, Meyer R, Canfield MA, Mulinare J.
[Read summary ]

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Use of Supplements Containing Folic Acid Among Women of Childbearing Age --- United States, 2007
Morbidity and Mortality Weekly Report; January 11, 2008; 57(01);5-8
Centers for Disease Control and Prevention
[Read article]

Trends in Blood Folate and Vitamin B-12 Concentrations in the United States, 1988-2004
The American Journal of Clinical Nutrition; 2007; 86:718-27
Pfeiffer CM, Johnson CL, Jain RB, Yetley EA, Picciano MF, Rader JI, Fisher KD, Mulinare J, Osterloh JD
[Read summary ]

Decline in the Prevalence of Spina Bifida and Anencephaly by Race/Ethnicity: 1995-2002
Pediatrics; 2005 September; 116:580-6
Williams LJ, Rasmussen SA, Flores A, Kirby RS, Edmonds LD
[Read summary ]

Folic Acid and the Prevention of Neural-Tube Defects
New England Journal of Medicine; 2004 May 20; 350:2209-11; author reply -11
Czeizel AE
[Read summary]

Prevention of Neural Tube Defects with Folic Acid in China
New England Journal of Medicine; 1999; 341 (20):1485-90
Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Want H, Mulinare J, Zhao P, Wong LY, Gindler J, Hong SX, Correa A, Hao L, Gunter E
[Read summary]

Recommendations for use of Folic Acid to Reduce Number of Spina Bifida Cases and Other Neural Tube Defects
Morbidity and Mortality Weekly Report; 1992; 41(RR-14):1-7
Centers for Disease Control and Prevention
[Read article]

Prevention of Neural Tube Defects: Results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group
Lancet; 1991; 338:131-7
[Read summary ]

Use of Folic Acid for Prevention of Spina Bifida and Other Neural Tube Defects -- 1983-1991
Morbidity and Mortality Weekly Report; 1991; 40:513-6.
Centers for Disease Control and Prevention
[Read summary ]

All Articles

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