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DPDx is an education resource designed for health professionals and laboratory scientists. For an overview including prevention and control visit www.cdc.gov/parasites/hymenolepis/.

Hymenolepiasis

[Hymenolepis diminuta] [Hymenolepis nana]

Egg of H. diminuta in an unstained wet mount.  Four hooks are clearly visible at this level of focus.

Egg of H. diminuta in an unstained wet mount. Four hooks are clearly visible at this level of focus.


H. nana egg in an unstained wet mount. Note the presence of hooks in the oncosphere and polar filaments within the space between the oncosphere and outer shell.

H. nana egg in an unstained wet mount. Note the presence of hooks in the oncosphere and polar filaments within the space between the oncosphere and outer shell.


Scolex of H. nana in an unstained wet mount of stool.  Image courtesy of Dr. David Bruckner.

Scolex of H. nana in an unstained wet mount of stool. Image courtesy of Dr. David Bruckner.

Causal Agents

Hymenolepiasis is caused by two cestodes (tapeworm) species, Hymenolepis nana (the dwarf tapeworm, adults measuring 15 to 40 mm in length) and Hymenolepis diminuta (rat tapeworm, adults measuring 20 to 60 cm in length). Hymenolepis diminuta is a cestode of rodents infrequently seen in humans and frequently found in rodents.

Life Cycles

Hymenolepis nana

Life cycle of Hymenolepis nana

Eggs of Hymenolepis nana are immediately infective when passed with the stool and cannot survive more than 10 days in the external environment The number 1. When eggs are ingested by an arthropod intermediate host The number 2 (various species of beetles and fleas may serve as intermediate hosts), they develop into cysticercoids, which can infect humans or rodents upon ingestion The number 3 and develop into adults in the small intestine. A morphologically identical variant, H. nana var. fraterna, infects rodents and uses arthropods as intermediate hosts. When eggs are ingested The number 4 (in contaminated food or water or from hands contaminated with feces), the oncospheres contained in the eggs are released. The oncospheres (hexacanth larvae) penetrate the intestinal villus and develop into cysticercoid larvae The number 5. Upon rupture of the villus, the cysticercoids return to the intestinal lumen, evaginate their scoleces The number 6, attach to the intestinal mucosa and develop into adults that reside in the ileal portion of the small intestine producing gravid proglottids The number 7. Eggs are passed in the stool when released from proglottids through its genital atrium or when proglottids disintegrate in the small intestine The number 8. An alternate mode of infection consists of internal autoinfection, where the eggs release their hexacanth embryo, which penetrates the villus continuing the infective cycle without passage through the external environment The number 9. The life span of adult worms is 4 to 6 weeks, but internal autoinfection allows the infection to persist for years.

Hymenolepis diminuta

Life cycle of Hymenolepis nana

Eggs of Hymenolepis diminuta are passed out in the feces of the infected definitive host (rodents, man) The number 1. The mature eggs are ingested by an intermediate host (various arthropod adults or larvae) The number 2, and oncospheres are released from the eggs and penetrate the intestinal wall of the host The number 3, which develop into cysticercoid larvae. Species from the genus Tribolium are common intermediate hosts for H. diminuta. The cysticercoid larvae persist through the arthropod's morphogenesis to adulthood. H. diminuta infection is acquired by the mammalian host after ingestion of an intermediate host carrying the cysticercoid larvae The number 4. Humans can be accidentally infected through the ingestion of insects in precooked cereals, or other food items, and directly from the environment (e.g., oral exploration of the environment by children). After ingestion, the tissue of the infected arthropod is digested releasing the cysticercoid larvae in the stomach and small intestine. Eversion of the scoleces The number 5 occurs shortly after the cysticercoid larvae are released. Using the four suckers on the scolex, the parasite attaches to the small intestine wall. Maturation of the parasites occurs within 20 days and the adult worms can reach an average of 30 cm in length The number 6. Eggs are released in the small intestine from gravid proglottids The number 7 that disintegrate after breaking off from the adult worms. The eggs are expelled to the environment in the mammalian host's feces The number 1.

Geographic Distribution

Hymenolepis nana is the most common cause of all cestode infections, and is encountered worldwide. In temperate areas its incidence is higher in children and institutionalized groups. Hymenolepis diminuta, while less frequent, has been reported from various areas of the world.

Clinical Presentation

Hymenolepis nana and H. diminuta infections are most often asymptomatic. Heavy infections with H. nana can cause weakness, headaches, anorexia, abdominal pain, and diarrhea.

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  • Page last reviewed November 29, 2013
  • Page last updated November 29, 2013
  • Content source: Global Health - Division of Parasitic Diseases and Malaria
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