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DPDx is an education resource designed for health professionals and laboratory scientists. For an overview including prevention and control visit www.cdc.gov/parasites/blastocystis.

Blastocystis hominis

[Blastocystis hominis]

Blastocystis hominis cyst-like forms in wet mounts under differential interference contrast (DIC) microscopy.

Blastocystis hominis cyst-like forms in wet mounts under differential interference contrast (DIC) microscopy.


B. hominis cyst-like forms in wet mounts under differential interference contrast (DIC) microscopy.

B. hominis cyst-like form in wet mounts under differential interference contrast (DIC) microscopy.


B. hominis cyst-like forms stained with trichrome. The nuclei in the peripheral cytoplasmic rim are visible, staining purple.

B. hominis cyst-like forms stained with trichrome. The nuclei in the peripheral cytoplasmic rim are visible, staining purple.

Causal Agents

The taxonomic classification of Blastocystis hominis is mired in controversy. It has been previously considered as yeasts, fungi, or ameboid, flagellated, or sporozoan protozoa. Recently, however, based on molecular studies, especially dealing with the sequence information on the complete SSUrRNA gene, B. hominis has been placed within an informal group, the stramenopiles (Silberman et al. 1996). Stramenopiles are defined, based on molecular phylogenies, as a heterogeneous evolutionary assemblage of unicellular and multicellular protists including brown algae, diatoms, chrysophytes, water molds, slime nets, etc. (Patterson, 1994). Cavalier-Smith (1998) considers stramenopiles to be identical to his infrakingdom Heterokonta under the kingdom Chromista. Therefore, according to Cavalier-Smith, B. hominis is a heterokontid chromista.

References:

  • Silberman JD, Sogin ML, Leipe DD, Clark CG. Human parasite finds taxonomic home. Nature 1996;380:398.
  • Patterson DJ. Protozoa, evolution and systematics. In: Housmann K, Hulsmann N, editors. Progress in Protozoology. Stuttgart: Fischer; 1994. p. 1-14.
  • Cavalier-Smith T. A revised six-kingdom system of life. Biol Rev Camb Philos Soc 1998;73:203-266.


Life Cycle

Life cycle of blastocystis

Blastocystis hominis stages were reproduced from Singh M, Suresh K, Ho LC, Ng GC, Yap EH. Elucidation of the life cycle of the intestinal protozoan Blastocystis hominis. Parasitol Res 1995;81:449. Copyright held by Springer-Verlag and reproduced here by permission of Springer-Verlag and M. Singh.

Knowledge of the life cycle and transmission is still under investigation, therefore this is a proposed life cycle for B. hominis. The classic form found in human stools is the cyst, which varies tremendously in size from 6 to 40 µm The Number 1. The thick-walled cyst present in the stools The Number 1 is believed to be responsible for external transmission, possibly by the fecal-oral route through ingestion of contaminated water or food The Number 2. The cysts infect epithelial cells of the digestive tract and multiply asexually (The Number 3, The Number 4 ). Vacuolar forms of the parasite give origin to multi vacuolar The Number 5a and ameboid forms The Number 5b. The multi-vacuolar develops into a pre-cyst The Number 6a that gives origin to a thin-walled cyst The Number 7a, thought to be responsible for autoinfection. The ameboid form gives origin to a pre-cyst The Number 6b, which develops into thick-walled cyst by schizogony The Number 7b. The thick-walled cyst is excreted in feces The Number 1.

Geographic Distribution

Worldwide.

Clinical Presentation

Whether Blastocystis hominis can cause symptomatic infection in humans is a point of active debate. This is because of the common occurrence of the organism in both asymptomatic and symptomatic persons. Those who believe symptoms could be related to infection with this parasite have described a spectrum of illness including watery diarrhea, abdominal pain, perianal pruritus, and excessive flatulence.

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  • Page last reviewed November 29, 2013
  • Page last updated November 29, 2013
  • Content source: Global Health - Division of Parasitic Diseases and Malaria
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