Table 22. Primary and Secondary Syphilis — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States, 2018–2022
| State/Territory | Cases | Rates per 100,000 Population | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 2018 | 2019 | 2020 | 2021 | 2022 | 2018 | 2019 | 2020 | 2021 | 2022 | |
| Alabama | 477 | 618 | 529 | 761 | 1,190 | 9.8 | 12.6 | 10.5 | 15.1 | 23.5 |
| Alaska | 55 | 129 | 176 | 194 | 160 | 7.5 | 17.6 | 24.0 | 26.5 | 21.8 |
| Arizona | 1,047 | 1,290 | 1,454 | 1,982 | 2,151 | 14.6 | 17.7 | 20.3 | 27.2 | 29.2 |
| Arkansas | 288 | 404 | 502 | 990 | 1,001 | 9.6 | 13.4 | 16.7 | 32.7 | 32.9 |
| California | 7,607 | 8,266 | 7,688 | 8,724 | 7,849 | 19.2 | 20.9 | 19.4 | 22.2 | 20.1 |
| Colorado | 337 | 486 | 640 | 772 | 918 | 5.9 | 8.4 | 11.1 | 13.3 | 15.7 |
| Connecticut | 91 | 210 | 280 | 329 | 248 | 2.5 | 5.9 | 7.8 | 9.1 | 6.8 |
| Delaware | 30 | 94 | 97 | 129 | 238 | 3.1 | 9.7 | 9.8 | 12.9 | 23.4 |
| District of Columbia | 279 | 308 | 247 | 257 | 271 | 39.7 | 43.6 | 35.8 | 38.4 | 40.3 |
| Florida | 2,880 | 3,189 | 3,520 | 4,498 | 4,618 | 13.5 | 14.8 | 16.3 | 20.7 | 20.8 |
| Georgia | 1,607 | 1,750 | 1,757 | 1,884 | 2,182 | 15.3 | 16.5 | 16.4 | 17.4 | 20.0 |
| Hawaii | 92 | 120 | 182 | 259 | 231 | 6.5 | 8.5 | 12.5 | 18.0 | 16.0 |
| Idaho | 46 | 47 | 66 | 84 | 118 | 2.6 | 2.6 | 3.6 | 4.4 | 6.1 |
| Illinois | 1,408 | 1,374 | 1,467 | 1,486 | 1,457 | 11.1 | 10.8 | 11.4 | 11.7 | 11.6 |
| Indiana | 367 | 336 | 527 | 734 | 686 | 5.5 | 5.0 | 7.8 | 10.8 | 10.0 |
| Iowa | 86 | 132 | 194 | 339 | 334 | 2.7 | 4.2 | 6.1 | 10.6 | 10.4 |
| Kansas | 152 | 190 | 150 | 301 | 347 | 5.2 | 6.5 | 5.1 | 10.3 | 11.8 |
| Kentucky | 366 | 438 | 445 | 513 | 670 | 8.2 | 9.8 | 9.9 | 11.4 | 14.8 |
| Louisiana | 669 | 700 | 704 | 995 | 1,225 | 14.4 | 15.1 | 15.1 | 21.5 | 26.7 |
| Maine | 74 | 55 | 38 | 61 | 82 | 5.5 | 4.1 | 2.8 | 4.4 | 5.9 |
| Maryland | 737 | 868 | 873 | NR | 781 | 12.2 | 14.4 | 14.1 | — | 12.7 |
| Massachusetts | 552 | 610 | 615 | 741 | 824 | 8.0 | 8.9 | 8.7 | 10.6 | 11.8 |
| Michigan | 649 | 678 | 787 | 972 | 972 | 6.5 | 6.8 | 7.8 | 9.7 | 9.7 |
| Minnesota | 292 | 385 | 417 | 565 | 675 | 5.2 | 6.8 | 7.3 | 9.9 | 11.8 |
| Mississippi | 464 | 690 | 741 | 829 | 913 | 15.5 | 23.2 | 25.0 | 28.1 | 31.1 |
| Missouri | 806 | 817 | 829 | 1,316 | 1,454 | 13.2 | 13.3 | 13.5 | 21.3 | 23.5 |
| Montana | 45 | 67 | 45 | 96 | 325 | 4.2 | 6.3 | 4.2 | 8.7 | 28.9 |
| Nebraska | 119 | 136 | 104 | 185 | 215 | 6.2 | 7.0 | 5.3 | 9.4 | 10.9 |
| Nevada | 682 | 808 | 767 | 939 | 902 | 22.5 | 26.2 | 24.7 | 29.9 | 28.4 |
| New Hampshire | 64 | 47 | 51 | 73 | 74 | 4.7 | 3.5 | 3.7 | 5.3 | 5.3 |
| New Jersey | 570 | 631 | 764 | 908 | 1,018 | 6.4 | 7.1 | 8.2 | 9.8 | 11.0 |
| New Mexico | 304 | 511 | 467 | 724 | 761 | 14.5 | 24.4 | 22.1 | 34.2 | 36.0 |
| New York | 2,654 | 2,865 | 3,022 | 3,500 | 3,603 | 13.6 | 14.7 | 15.0 | 17.6 | 18.3 |
| North Carolina | 1,098 | 1,122 | 1,322 | 1,870 | 2,473 | 10.6 | 10.7 | 12.7 | 17.7 | 23.1 |
| North Dakota | 41 | 45 | 32 | 49 | 64 | 5.4 | 5.9 | 4.1 | 6.3 | 8.2 |
| Ohio | 740 | 749 | 1,084 | 1,783 | 2,402 | 6.3 | 6.4 | 9.2 | 15.1 | 20.4 |
| Oklahoma | 531 | 791 | 941 | 1,225 | 1,278 | 13.5 | 20.0 | 23.8 | 30.7 | 31.8 |
| Oregon | 424 | 454 | 628 | 949 | 1,117 | 10.1 | 10.8 | 14.8 | 22.3 | 26.3 |
| Pennsylvania | 797 | 991 | 1,046 | 1,310 | 1,397 | 6.2 | 7.7 | 8.0 | 10.1 | 10.8 |
| Rhode Island | 96 | 101 | 89 | 209 | 133 | 9.1 | 9.5 | 8.1 | 19.1 | 12.2 |
| South Carolina | 384 | 516 | 652 | 836 | 1,033 | 7.6 | 10.0 | 12.7 | 16.1 | 19.6 |
| South Dakota | 41 | 48 | 66 | 436 | 767 | 4.6 | 5.4 | 7.4 | 48.7 | 84.3 |
| Tennessee | 553 | 676 | 767 | 952 | 1,126 | 8.2 | 9.9 | 11.1 | 13.6 | 16.0 |
| Texas | 2,538 | 2,357 | 2,708 | 3,865 | 4,655 | 8.8 | 8.1 | 9.3 | 13.1 | 15.5 |
| Utah | 169 | 138 | 131 | 205 | 238 | 5.3 | 4.3 | 4.0 | 6.1 | 7.0 |
| Vermont | 11 | 11 | 3 | 9 | 3 | 1.8 | 1.8 | 0.5 | 1.4 | 0.5 |
| Virginia | 702 | 659 | 701 | 745 | 936 | 8.2 | 7.7 | 8.1 | 8.6 | 10.8 |
| Washington | 802 | 816 | 836 | 1,506 | 1,920 | 10.6 | 10.7 | 10.8 | 19.5 | 24.7 |
| West Virginia | 65 | 79 | 127 | 212 | 218 | 3.6 | 4.4 | 7.1 | 11.9 | 12.3 |
| Wisconsin | 152 | 179 | 366 | 723 | 742 | 2.6 | 3.1 | 6.2 | 12.3 | 12.6 |
| Wyoming | 23 | 11 | 11 | 16 | 21 | 4.0 | 1.9 | 1.9 | 2.8 | 3.6 |
| US TOTAL | 35,063 | 38,992 | 41,655 | 53,767 | 59,016 | 10.7 | 11.9 | 12.6 | 16.2 | 17.7 |
| Northeast | 4,909 | 5,521 | 5,908 | 7,140 | 7,382 | 8.7 | 9.9 | 10.3 | 12.5 | 12.9 |
| Midwest | 4,853 | 5,069 | 6,023 | 8,889 | 10,115 | 7.1 | 7.4 | 8.7 | 12.9 | 14.7 |
| South | 13,668 | 15,259 | 16,633 | 21,288 | 24,808 | 11.0 | 12.2 | 13.2 | 16.7 | 19.3 |
| West | 11,633 | 13,143 | 13,091 | 16,450 | 16,711 | 14.9 | 16.8 | 16.7 | 20.9 | 21.2 |
| American Samoa | 0 | 0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Commonwealth of the Northern Mariana Islands | 1 | 1 | 2 | 0 | 0 | 1.9 | 1.9 | 3.9 | 0.0 | 0.0 |
| Guam | 18 | 5 | 5 | 7 | 2 | 10.7 | 3.0 | 3.0 | 4.1 | 1.2 |
| Puerto Rico | 365 | 329 | 276 | 332 | 380 | 11.1 | 10.3 | 8.4 | 10.2 | 11.8 |
| US Virgin Islands | NR | NR | 4 | 2 | 6 | — | — | 3.8 | 1.9 | 5.7 |
| TERRITORIES TOTAL | 384 | 335 | 287 | 341 | 388 | 10.8 | 9.7 | 7.8 | 9.4 | 10.8 |
| TOTAL | 35,447 | 39,327 | 41,942 | 54,108 | 59,404 | 10.7 | 11.9 | 12.5 | 16.1 | 17.6 |
| NR = No report. NOTE: See Technical Notes for more information on syphilis case reporting and on interpreting case counts and rates in US territories. This report includes data from years that coincide with the COVID-19 pandemic, which introduced uncertainty and difficulty in interpreting case data. See Impact of COVID-19 on STIs for more information. Due to a network security incident in December 2021, the Maryland Department of Health could not finalize their 2021 STI case notification data. Although 2021 data from Maryland are included in national and regional case counts and rates displayed in this table, state-specific data have been suppressed. |
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