Resources for Health Professionals


Examples of several of the most commonly used treatments are provided in the table below. As always, treatment decisions should be individualized.

Drug* Dosage regimen for adults
Iodoquinol 650 mg orally three times daily for 20 days
Paromomycin 25–35 mg per kg per day orally, in three divided doses, for 7 days
Metronidazole** 500–750 mg orally three times daily for 10 days

*Not FDA-approved for this indication.

** Metronidazole is a nitroimidazole drug. The nitroimidazole drugs secnidazole and ornidazole have been used to treat D. fragilis infection but are unavailable in the United States.

Iodoquinol is available for human use in the United States.

Oral paromomycin is available for human use in the United States.

Metronidazole is available for human use in the United States.


  • Stark D, Barratt J, Roberts T, et al. A review of the clinical presentation of dientamoebiasis. Am J Trop Med Hyg 2010;82:614–9.
  • Kurt O, Girginkardesler N, Balcioglu IC, et al. A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis. Clin Microbiol Infect 2008;14:601–4.
  • Vandenberg O, Souayah H, Mouchet F, et al. Treatment of Dientamoeba fragilis infection with paromomycin. Pediatr Infect Dis J 2007;26:88–90.
  • Vandenberg O, Peek R, Souayah H, et al. Clinical and microbiological features of dientamoebiasis in patients suspected of suffering from a parasitic gastrointestinal illness: a comparison of Dientamoeba fragilis and Giardia lamblia infections. Int J Infect Dis 2006;10:255–61.
  • Girginkardesler N, Coskun S, Balcioglu IC, et al. Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole. Clin Microbiol Infect 2003;9:110–3.
  • Norberg A, Nord CE, Evengard B. Dientamoeba fragilis—a protozoal infection which may cause severe bowel distress. Clin Microbiol Infect 2003;9:65–8.
  • Preiss U, Ockert G, Broemme S, et al. On the clinical importance of Dientamoeba fragilis infections in childhood. J Hyg Epidemiol Microbiol Immunol 1991;35:27-34.

This information is provided as an informational resource for licensed health care providers as guidance only. It is not intended as a substitute for professional judgment.




Page last reviewed: December 17, 2012