Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 7722–84–1
NIOSH REL: 1 ppm (1.4 mg/m3) TWA
Current OSHA PEL: 1 ppm (1.4 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 1 ppm (1.4 mg/m3) TWA
Description of Substance: Colorless liquid with a slightly sharp odor.
LEL:. . Noncombustible Liquid
Original (SCP) IDLH: 75 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by AIHA  that the short exposure tolerance is unknown for man, but is probably 75 ppm. AIHA  also reported that a single 4hour exposure to 75 ppm was tolerated by mice but higher concentrations produced delayed deaths [Svirbely]. According to AIHA , concentrations in excess of 1,000 ppm would probably be lethal after a few minutes [Svirbely].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Species||Reference||LC50(ppm)||LCLo(ppm)||Time||Adjusted 0.5-hrLC (CF)||Derived value|
|Rat||Gig Tr Prof Zabol 1977||1,418||—–||4 hr||2,836 ppm (2.0)||284 ppm|
|Mouse||Stokinger & Scheel 1962||—–||227||?||?||?|
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|Mouse||Lyazsky et al. 1983||oral||2,000||—–||9,929 ppm||993 ppm|
Other animal data: It has been reported that mice tolerated a single 4hour exposure to 75 ppm [Svirbely].
Human data: It has been stated that although the shortterm exposure tolerance is unknown, it is probably about 75 ppm [AIHA 1957]. Death has resulted in a man who drank 100 ml [Raukhverger and Solodko 1974].
|Revised IDLH: 75 ppm [Unchanged]Basis for revised IDLH: Based on acute inhalation data in humans [AIHA 1957] and animals [Svirbely], the original IDLH for hydrogen peroxide (75 ppm) is not being revised at this time.|
1. AIHA . Hydrogen peroxide (90%). In: Hygienic guide series. Am Ind Hyg Assoc Q 18:275276.
2. Gig Tr Prof Zabol ; 21(10):2225 (in Russian).
3. Lyazsky PP, Gleiberman SE, et al. . Toxicological and hygienic characterization of decontaminating preparations based on hydrogen peroxide and its derivatives. Gig Sanit 48(6):2831 (in Russian).
4. Raukhverger AB, Solodko ON . Intoxication with concentrated hydrogen peroxide. SudebnoMeditsinkaya Ekspertiza (Forensic Medical Examination) 17(1):5354 (in Russian).
5. Stokinger HE, Scheel LD . Ozone toxicity: immunochemical and toleranceproducing aspects. Arch Environ Health 4:327334.
6. Svirbely JL [?]. Unpublished results. Cincinnati, OH: U.S. Public Health Service. [From AIHA . Hydrogen peroxide (90%). In: Hygienic guide series. Am Ind Hyg Assoc Q 18:275276.]