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May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number; 534-52-1

NIOSH REL: 0.2 mg/m3 TWA [skin]

Current OSHA PEL: 0.2 mg/m3 TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.2 mg/m3 TWA [skin]

Description of Substance: Yellow, odorless solid.

LEL:. . Unknown

Original (SCP) IDLH: 5 mg/m3

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Hunter [1969] that 4.7 mg/m3 per day caused the following symptoms in a factory worker: fever, weight loss, a 400% rise in the basal rate of metabolism, rapid pulse, rapid respiration, profuse sweating, shortness of breath, and cough [McDonald 1943]. It is obvious that the chosen IDLH has been set conservatively, but no other quantitative data are available on which to base an IDLH.

Short-term exposure guidelines: None developed


Lethal concentration data:

Species Reference LC50 LCLo Time Adjusted 0.5-hrLC (CF) Derivedvalue
Cat Burkatskaya 1965 LC33: 40 mg/m3 —– 4 hr 80 mg/m3 (2.0) 8.0 mg/m3


Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value



G. pig


Colliot 1972DeCeaurriz et al. 1981

MacEwen and Vernot 1972

Popov and Vrochinsky 1976

Popov and Vrochinsky 1976

Spencer et al. 1948
















49 mg/m3350 mg/m3

147 mg/m3

172 mg/m3

172 mg/m3

217 mg/m3

4.9 mg/m335 mg/m3

15 mg/m3

17 mg/m3

17 mg/m3

22 mg/m3


Human data: An exposure of 4.7 mg/m3 per day resulted in fever, a basal metabolic rate of 400, rapid pulse and respiration, profuse sweating, shortness of breath, and cough [Fairhall 1957]. A single oral dose 75 mg produced no toxic effects in five volunteers [Harvey et al. 1951]. [Note: An oral dose of 75 mg is equivalent to a worker being exposed to 50 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Revised IDLH: 5 mg/m3 [Unchanged]Basis for revised IDLH: Based on acute toxicity data in humans [Fairhall 1957; Harvey et al. 1951] and animals [Colliot 1972], the original IDLH for dinitro-o-cresol (5 mg/m3) is not being revised at this time.



1. Burkatskaya EN [1965]. Maximum permissible concentration of dinitro-o-cresol in air. Gig Tr Prof Zabol 30:34-37 (in Russian).

2. Colliot F [1972]. Intérêt présenté par l’acétate de dinoterbe pour le traitement d’hiver des arbres fruitiers et de la vigne. Defensi des Vegetaux 26:69-84 (in French).

3. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett 9(4):137-143.

4. Fairhall LT [1957]. Industrial toxicology. 2nd ed. Baltimore, MD: Williams & Wilkins Company, p. 230.

5. Harvey DG, Bidstrup PL, Bonnell JAL [1951]. Poisoning by dinitro-ortho-cresol. Some observations on the effects of dinitro-ortho-cresol administered by mouth to human volunteers. Br J Med 2:13-15.

6. Hunter D [1969]. Dinitro-ortho-cresol. In: The diseases of occupations. 4th ed. Boston, MA: Little, Brown and Company, pp. 559-567.

7. MacEwen JD, Vernot EH [1972]. Toxic Hazards Research Unit annual report: 1972. Wright-Patterson Air Force Base, OH: Air Force Systems Command, Aerospace Medical Division, Aerospace Medical Research Laboratory Report, AMRL-TR-72-62.

8. McDonald JM [1943]. Industrial hygiene in wartime Baltimore. Baltimore Health News 20(9):169-170.

9. Popov TA, Vrochinsky KK [1976]. Materials on substantiation of the threshold of DNOC in water bodies. Gig Sanit 41(6):12-15 (in Russian).

10. Spencer HC, Rowe VK, Adams EM, Irish DD [1948]. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol 30:10-28.