n-Butyl glycidyl ether

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 2426–08–6

NIOSH REL: 5.6 ppm (30 mg/m3) 15-minute CEILING

Current OSHA PEL: 50 ppm (270 mg/m3) TWA

1989 OSHA PEL: 25 ppm (135 mg/m3) TWA

1993-1994 ACGIH TLV: 25 ppm (133 mg/m3) TWA

Description of Substance: Colorless liquid with an irritating odor.

LEL: . . Unknown

Original (SCP) IDLH: 3,500 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that the mouse 4-hour LC50 was greater than 3,500 ppm [Hine et al. 1956].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species Reference LC50(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) Derivedvalue
MouseRat Hine et al. 1956Hine et al. 1956 >3,5001,030 ———- 4 hr8 hr >7,000 ppm (2.0)2,575 ppm (2.5) >700 ppm258 ppm

 

Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value
MouseRat Hine et al. 1956Smyth et al. 1962 oraloral 1,5302,050 ———- 1,980 ppm2,652 ppm 198 ppm265 ppm

 

Human data: None relevant for use in determining the revised IDLH.

 

REFERENCES:

1. ACGIH [1971]. n-Butyl glycidyl ether (BGE). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 33.

2. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.

Page last reviewed: December 4, 2014