Dichloroethyl ether

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 111–44–4

NIOSH REL: 5 ppm (30 mg/m3) TWA, 10 ppm (60 mg/m3) STEL [skin]; NIOSH considers dichloroethyl ether to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 15 ppm (90 mg/m3) CEILING [skin]

1989 OSHA PEL: 5 ppm (30 mg/m3) TWA, 10 ppm (60 mg/m3) STEL [skin]

1993-1994 ACGIH TLV: 5 ppm (29 mg/m3) TWA, 10 ppm (58 mg/m3) STEL [skin]

Description of Substance: Colorless liquid with a chlorinated solvent-like odor.

LEL:. . 2.7% (10% LEL, 2,700 ppm)

Original (SCP) IDLH: 250 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Patty [1963] that 250 ppm caused death in rats from a 4-hour exposure [Carpenter et al. 1949] and that 500 to 1000 ppm might cause death in guinea pigs from an exposure of only 30 to 60 minutes duration [Schrenk et al. 1933].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species Reference LC50(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) Derivedvalue
RatRat

Mouse

G. pig

G. pig

Carpenter et al. 1949Izmerov et al. 1982

Izmerov et al. 1982

Marhold 1986

Schrenk et al. 1933

—–77

152

500

—–

250—–

—–

—–

500

4 hr4 hr

2 hr

1 hr

5 hr

500 ppm (2.0)154 ppm (2.0)

243 ppm (1.6)

625 ppm (1.25)

1,075 ppm (2.15)

50 ppm15 ppm

24 ppm

63 ppm

108 ppm

 

Human data: Volunteers found brief (undefined) exposures to 100 to 260 ppm to be tolerable, although irritating [Schrenk et al. 1933].

 

REFERENCES:

1. Carpenter CP, Smyth HF Jr, Pozzani C [1949]. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol 31:343-346.

2. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 45.

3. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 541 (in Czechoslovakian).

4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1675.

5. Schrenk HH, Patty FA, Yant WP [1933]. Acute response of guinea pigs to vapors of some new commercial organic compounds. VII. Dichloroethyl ether. Public Health Rep 48(46):1389-1398.

Page last reviewed: December 4, 2014