Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 110–80–5
NIOSH REL: 0.5 ppm (1.8 mg/m3) TWA [skin]
Current OSHA PEL: 200 ppm (740 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 5 ppm (18 mg/m3) TWA [skin]
Description of Substance: Colorless liquid with a sweet, pleasant, ether-like odor.
LEL(@200 F): 1.7% (10% LEL(@200 F), 1,700 ppm)
Original (SCP) IDLH: 6,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by AIHA  that investigators concluded from animal experiments that substantially saturated atmospheres (6,000 ppm) at ordinary room temperatures will not produce serious injury in 1 hour [Waite et al. 1930].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Species||Reference||LC50(ppm)||LCLo(ppm)||Time||Adjusted 0.5-hrLC (CF)||Derivedvalue|
|NPIRI 1974Waite et al. 1930
Werner et al. 1943
|7 hr24 hr
|4,800 ppm (2.4)10,950 ppm (3.65)
4,368 ppm (2.4)
|480 ppm1,095 ppm
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|MouseRat||Eastman 1982Gig Tr Prof Zabol 1963||oraloral||2,4512,125||———-||4,575 ppm3,967 ppm||458 ppm397 ppm|
Other animal data: Some investigators have stated that at ordinary room temperatures substantially saturated atmospheres (i.e., about 6,000 ppm) will not produce serious injury in 1 hour [Waite et al. 1930].
Human data: Volunteers with some work experience reported that odor levels of 125 ppm were noticeable and that the odor level that would be intolerable was greater than 255 ppm [Clayton and Clayton 1982].
|Revised IDLH: 500 ppmBasis for revised IDLH: The revised IDLH for 2-ethoxyethanol is 500 ppm based on acute inhalation toxicity data in animals [NPIRI 1974; Werner et al. 1943]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 255 ppm.|
1. AIHA . Ethylene glycol monoethyl ether (2-ethoxyethanol). In: Hygienic guide series. Am Ind Hyg Assoc J 24:288-289.
2. Clayton GD, Clayton FE, eds. . Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2C. Toxicology. New York: John Wiley & Sons, Inc., p. 3926.
3. Eastman Chemical Products . Material safety data sheet: EKTASOLVE® EE solvent. Kingsport, TN: Eastman Chemical Products, Inc., MSDS-10, 170A-1 (10-82), pp. 1-7.
4. Gig Tr Prof Zabol ; 32(3):48-54 (in Russian).
5. NPIRI . Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 54.
6. Waite CP, Patty FA, Yant WP . Acute response of guinea pigs to vapors of some new commercial organic compounds. III. “Cellosolve” (mono-ethyl ether of ethylene glycol). Public Health Rep 45:1459-1466.
7. Werner HW, Mitchell JL, Miller JW, von Oettingen WF . Acute toxicity of vapors of several monoalkyl ethers of ethylene glycol. J Ind Hyg Toxicol 25:157-163.