Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 109–89–7
NIOSH REL: 10 ppm (30 mg/m3) TWA, 25 ppm (75 mg/m3) STEL
Current OSHA PEL: 25 ppm (75 mg/m3) TWA
1989 OSHA PEL: 10 ppm (30 mg/m3) TWA, 25 ppm (75 mg/m3) STEL
1993-1994 ACGIH TLV: 5 ppm (15 mg/m3) TWA, 15 ppm (45 mg/m3) STEL [skin]
Description of Substance: Colorless liquid with a fishy, ammonia-like odor.
LEL:. . 1.8% (10% LEL, 1,800 ppm)
Original (SCP) IDLH: 2,000 ppm
Basis for original (SCP) IDLH: Patty  made the statement that a 4-hour exposure to 4,000 ppm killed 3 of 6 rats. However, because of the severe eye and lung irritation that occurs as a result of exposure to high concentrations of diethylamine, an IDLH of 2,000 ppm is chosen.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Species||Reference||LC50(ppm)||LCLo(ppm)||Time||Adjusted 0.5-hrLC (CF)||Derivedvalue|
|Rat||Hine et al. 1960||4,000||—–||4 hr||8,000 ppm (2.0)||800 ppm|
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|RatMouse||Hine et al. 1960Patel et al. 1985||oraloral||540500||———-||1,243 ppm1,151 ppm||124 ppm115 ppm|
Other animal data: RD50 (mouse), 184 ppm [Nielsen and Yamagiwa 1989].
Human data: It has been stated that the simple alkyl amines are generally more toxic than ammonia [ACGIH 1991]. The American Conference of Governmental Industrial Hygienists TLV for diethylamine (10 ppm TWA, 25 ppm STEL) was based on an analogy to ammonia (25 ppm TWA, 35 ppm STEL) [ACGIH 1991].
|Revised IDLH: 200 ppmBasis for revised IDLH: The revised IDLH for diethylamine is 200 ppm based on acute inhalation toxicity data in animals [Nielsen and Yamagiwa 1989] and an analogy to ammonia [ACGIH 1991].|
1. ACGIH . Diethylamine. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 460-461.
2. Hine CH, Kodama JK, Guzman RJ, Loquvam GS . The toxicity of allylamines. Arch Environ Health 1:343-352.
3. Nielsen GD, Yamagiwa M . Structure-activity relationships of airway irritating aliphatic amines, receptor activation mechanisms and predicted industrial exposure limits. Chem Biol Interact 71(2/3):228-244.
4. Patel VK, Venkatakrishna-Bhatt H, Patel NB, Jindal MN . Pharmacology of new glutarimide compounds. Biomed Biochim Acta 44(5):795-803.
5. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2044.
- Page last reviewed: December 4, 2014
- Page last updated: December 4, 2014
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