Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 108–84–9
NIOSH REL: 50 ppm (300 mg/m3) TWA
Current OSHA PEL: 50 ppm (300 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 50 ppm (295 mg/m3) TWA
Description of Substance: Colorless liquid with a mild, pleasant, fruity odor.
LEL:. . Unknown
Original (SCP) IDLH: 4,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH  that 2 of 6 rats died from a 4-hour exposure to 4,000 ppm [Smyth et al. 1954].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Species||Reference||LC50(ppm)||LCLo(ppm)||Time||Adjusted 0.5-hrLC (CF)||Derivedvalue|
|RatRat||Smyth et al. 1954UCC 1966||LC33: 4,000—–||—–2,000||4 hr4 hr||8,000 ppm (2.0)4,000 ppm (2.0)||800 ppm400 ppm|
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|Rat||UCC 1966||oral||6,160||—–||7,187 ppm||719 ppm|
Human data: Volunteers noted an unpleasant odor and irritation of the eyes and upper respiratory tract at 100 ppm [Silverman et al. 1946].
|Revised IDLH: 500 ppmBasis for revised IDLH: The revised IDLH for sec-hexyl acetate is 500 ppm based on acute inhalation toxicity data in humans [Silverman et al. 1946] and animals [Smyth et al. 1954; UCC 1966].|
1. ACGIH . sec-Hexyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 127.
2. Silverman L, Schulte HF, First MW . Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC . Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.
4. UCC . Toxicology studies: methyl amyl acetate. New York, NY: Union Carbide Corporation, Industrial Medicine and Toxicology Department (7/28/66).