sec-Hexyl acetate

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 108–84–9

NIOSH REL: 50 ppm (300 mg/m3) TWA

Current OSHA PEL: 50 ppm (300 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 50 ppm (295 mg/m3) TWA

Description of Substance: Colorless liquid with a mild, pleasant, fruity odor.

LEL:. . Unknown

Original (SCP) IDLH: 4,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that 2 of 6 rats died from a 4-hour exposure to 4,000 ppm [Smyth et al. 1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species Reference LC50(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) Derivedvalue
RatRat Smyth et al. 1954UCC 1966 LC33: 4,000—– —–2,000 4 hr4 hr 8,000 ppm (2.0)4,000 ppm (2.0) 800 ppm400 ppm

 

Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value
Rat UCC 1966 oral 6,160 —– 7,187 ppm 719 ppm

 

Human data: Volunteers noted an unpleasant odor and irritation of the eyes and upper respiratory tract at 100 ppm [Silverman et al. 1946].

 

REFERENCES:

1. ACGIH [1971]. sec-Hexyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 127.

2. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

4. UCC [1966]. Toxicology studies: methyl amyl acetate. New York, NY: Union Carbide Corporation, Industrial Medicine and Toxicology Department (7/28/66).

Page last reviewed: December 4, 2014