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Diisobutyl ketone

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 108–83–8

NIOSH REL: 25 ppm (150 mg/m3) TWA

Current OSHA PEL: 50 ppm (290 mg/m3) TWA

1989 OSHA PEL: 25 ppm (150 mg/m3) TWA

1993-1994 ACGIH TLV: 25 ppm (145 mg/m3) TWA

Description of Substance: Colorless liquid with a mild, sweet odor.

LEL(@200 F): 0.8% (10% LEL(@200 F), 800 ppm)

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that “breathing saturated vapors in air killed 1 of 6 animals in 8 hours; breathing 2,000 ppm for 8 hours killed 5 of 6 animals. Breathing 1,000 ppm for 8 hours produced illness but no deaths.” This is the only useful data available on which to base the IDLH for this substance.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species Reference LC50(ppm) LCLo(ppm) Time Adjusted 0.5-hrLC (CF) Derivedvalue
RatRat Smyth et al. 1949Smyth et al. 1949 —–2,000 2,000—– 4 hr8 hr 4,000 ppm (2.0)5,000 ppm (2.5) 400 ppm500 ppm

Lethal dose data:

Species Reference Route LD50(mg/kg) LDLo(mg/kg) Adjusted LD Derived value
RatMouse

Rat

NPIRI 1974Shell 1961

Smyth et al. 1949

oraloral

oral

5,7501,416

5,800

———-

—–

6,799 ppm1,674 ppm

6,858 ppm

680 ppm167 ppm

686 ppm

 

Human data: It has been reported that a 3-hour exposure at 50 or 100 ppm caused slight irritation to the eyes, nose, and throat [Smyth et al. 1949].

Revised IDLH: 500 ppmBasis for revised IDLH: The revised IDLH for diisobutyl ketone is 500 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].

 

REFERENCES:

1. Carpenter CP, Pozzani UC, Weil CS [1953]. Toxicity and hazard of diisobutyl ketone vapors. AMA Arch Ind Hyg Occup Med 8:377-381.

2. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 23.

3. Shell [1961]. Unpublished report. Shell Chemical Company, p. 4.

4. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range-finding toxicity data: list III. J Ind Hyg Toxicol 31:60-62.

5. UCC [1971]. Toxicology studies: diisobutyl ketone. New York, NY: Union Carbide Corporation.

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