Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 108–83–8
NIOSH REL: 25 ppm (150 mg/m3) TWA
Current OSHA PEL: 50 ppm (290 mg/m3) TWA
1989 OSHA PEL: 25 ppm (150 mg/m3) TWA
1993-1994 ACGIH TLV: 25 ppm (145 mg/m3) TWA
Description of Substance: Colorless liquid with a mild, sweet odor.
LEL(@200 F): 0.8% (10% LEL(@200 F), 800 ppm)
Original (SCP) IDLH: 2,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC  report that “breathing saturated vapors in air killed 1 of 6 animals in 8 hours; breathing 2,000 ppm for 8 hours killed 5 of 6 animals. Breathing 1,000 ppm for 8 hours produced illness but no deaths.” This is the only useful data available on which to base the IDLH for this substance.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Species||Reference||LC50(ppm)||LCLo(ppm)||Time||Adjusted 0.5-hrLC (CF)||Derivedvalue|
|RatRat||Smyth et al. 1949Smyth et al. 1949||—–2,000||2,000—–||4 hr8 hr||4,000 ppm (2.0)5,000 ppm (2.5)||400 ppm500 ppm|
Lethal dose data:
|Species||Reference||Route||LD50(mg/kg)||LDLo(mg/kg)||Adjusted LD||Derived value|
|NPIRI 1974Shell 1961
Smyth et al. 1949
|6,799 ppm1,674 ppm
|680 ppm167 ppm
Human data: It has been reported that a 3-hour exposure at 50 or 100 ppm caused slight irritation to the eyes, nose, and throat [Smyth et al. 1949].
|Revised IDLH: 500 ppmBasis for revised IDLH: The revised IDLH for diisobutyl ketone is 500 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].|
1. Carpenter CP, Pozzani UC, Weil CS . Toxicity and hazard of diisobutyl ketone vapors. AMA Arch Ind Hyg Occup Med 8:377-381.
2. NPIRI . Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 23.
3. Shell . Unpublished report. Shell Chemical Company, p. 4.
4. Smyth HF Jr, Carpenter CP, Weil CS . Range-finding toxicity data: list III. J Ind Hyg Toxicol 31:60-62.
5. UCC . Toxicology studies: diisobutyl ketone. New York, NY: Union Carbide Corporation.
- Page last reviewed: December 4, 2014
- Page last updated: December 4, 2014
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