Recent Publications
The journal articles below are recent publications authored or co-authored by VSPB staff.
COVID-19 publications
VSPB has played an active role in CDC’s COVID-19 response since the start of the pandemic, when staff set up sampling and testing programs at ship quarantine sites. Since then, VSPB has supported our partners through technical assistance and capacity building to improve infection prevention and control measures and laboratory diagnostics. These contributions have led to novel discoveries, like the development of a low-cost method for decontaminating PPE for reuse and improved US and global diagnostic testing capabilities. The following publications describe VSPB’s activities throughout the COVID-19 pandemic.
Ritter JM, Wilson TM, Gary JM. Histopathology and localization of SARS-CoV-2 and its host cell entry receptor ACE2 in tissues from naturally infected US-farmed mink (Neovison vison)external icon. 1 March 2022. Veterinary Pathology.
Lendvay TL, Chen J, Harcourt BH, Scholte FEM, et al. 2020. Addressing personal protective equipment (PPE) decontamination: Methylene blue and light inactivates SARS-CoV-2 on N95 respirators and masks with maintenance of integrity and fitexternal icon. 21 May 2021, Infection Control and Hospital Epidemiology.
Humeyestewa D, Burke RM, Kaur H, et al. COVID-19 response by the Hopi Tribe: impact of systems improvement during the first wave on the second wave of the pandemicexternal icon. BMJ Glob Health. 2021 May;6(5):e005150.
Mayer O, Pfundt T, Fortenberry GZ, Harcourt BH, and Bower WA. 2020. Lessons learned from a COVID-19 biohazard spill during swabbing at a quarantine facilityexternal icon. Dis Med Pub Health Prep. 5 Nov 2020;p1-9.
Jenkins R, Burke RM, Hamilton J, Fet al. Notes from the Field: Development of an Enhanced Community-Focused COVID-19 Surveillance Program – Hopi Tribe, June‒July 2020. MMWR Morb Mortal Wkly Rep. 2020 Nov 6;69(44):1660-1661.
Hirschman J, Kaur H, Honanie K, et al. A SARS-CoV-2 Outbreak Illustrating the Challenges in Limiting the Spread of the Virus – Hopi Tribe, May-June 2020. MMWR Morb Mortal Wkly Rep. 2020 Nov 6;69(44):1654-1659.
Ip HS, Griffin KM, Messer JD, et al. An opportunistic survey reveals an unexpected coronavirus diversity hotspot in North Americaexternal icon. Viruses. Oct 2021. 13, 2016.
Goryoka GW, Cossaboom CM, Gharpure R, Dawson P, Tansey C, et al. One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases—Utah and Wisconsinexternal icon, 2020 Sept 12. Viruses. 2021, 13, 1813.
Cossaboom CM, Medley AM, Spengler JR, et al. Low SARS-CoV-2 Seroprevalence and No Active Infections among Dogs and Cats in Animal Shelters with Laboratory-Confirmed COVID-19 Human Cases among Employeesexternal icon. Biology. 2021 Sept 11, 10, 898.
Havers FP, Reed C, Lim T, Montgomery JM, Klena JD, et al. Seroprevalence of antibodies to SARS-CoV-2 in 10 sites in the United States, March 23-May 12, 2020external icon. JAMA Intern Med. 2020 Jul 21.
Freeman B, Lester S, Mills L, et al. Validation of a SARS-CoV-2 spike protein ELISA for use in contact investigations and serosurveillanceexternal icon. bioRxiv. 2020 Apr 25:2020.
Umair M, Ikram A, Salman M, et al. Whole-genome sequencing of SARS-CoV-2 reveals the detection f G614 variant in Pakistanexternal icon. PLoS One. 2021 Mar 23;16(3):e0248371.
Publications by Year
Lo MK, Shrivastava-Ranjan P, Chatterjee P, et al. Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524)external icon. Microbiol Spectr. 2021 Dec 22;9(3):e0153721.
Kofman A, Linderman S, Su K, et al. Characteristics of Ebola virus disease survivors in blood and semen in Liberia: serology and reverse transcriptase polymerase chain reaction (RT-PCR)external icon. Clin Infect Dis. 2021 Dec 6;73(11)
Schuh AJ, Kyondo J, Graziano J, et al. Rapid establishment of a frontline field laboratory in response to an imported outbreak of Ebola virus disease in western Uganda, June 2019external icon. PLoS Negl Trop Dis. 2021 Dec 3;15(12):e0009967.
Amman BR, Schuh AJ, Albariño CG, Towner JS. Marburg Virus Persistence on Fruit as a Plausible Route of Bat to Primate Filovirus Transmissionexternal icon. Viruses. 2021 Nov 30;13(12):2394.
Barbeau DJ, Cartwright HN, Harmon JR, et al. Identification and Characterization of Rift Valley Fever Virus-Specific T Cells Reveals a Dependence on CD40/CD40L Interactions for Prevention of Encephalitisexternal icon. J Virol. 2021 Nov 9;95(23):e0150621.
Hills SL, Broussard KR, Broyhill JC, et al. Tick-borne encephalitis among US travellers, 2010-20external icon. J Travel Med. 2021 Nov 6:taab167.
Tilston-Lunel NL, Welch SR, Nambulli S, et al. Sustained Replication of Synthetic Canine Distemper Virus Defective Genomesexternal icon In Vitro and In Vivo. mSphere. 2021 Oct 27;6(5):e0053721.
Balinandi S, Whitmer S, Mulei S, et al. Clinical and Molecular Epidemiology of Crimean-Congo Hemorrhagic Fever in Humans in Uganda, 2013-201external icon9. Am J Trop Med Hyg. 2021 Oct 18:tpmd210685.
Hoyos J, Carrasquilla MC, León C, et al. Host selection pattern and flavivirus screening of mosquitoes in a disturbed Colombian rainforestexternal icon. Sci Rep. 2021 Sep 20;11(1):18656.
Lo MK, Shrivastava-Ranjan P, Chatterjee P, et al. Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)external icon. bioRxiv [Preprint]. 2021 Aug 10:2021.08.06.455494.
Agnihotri S, Alpren C, Bangura B, et al. Building the Sierra Leone Ebola database: organization and characteristics of data systematically collected during 2014-2015 Ebola epidemicexternal icon. Ann Epidemiol. 2021 Aug;60:35-44.
Spengler JR, Welch SR, Scholte FEM, et al. Viral replicon particles protect IFNAR -/- mice against lethal Crimean-Congo hemorrhagic fever virus challenge three days after vaccinationexternal icon. Antiviral Res. 2021 Jul;191:105090.
Welch SR, Spengler JR, Genzer SC, et al. Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platformexternal icon. Viruses. 2021 Jun 28;13(7):1255.
Larson PA, Bartlett ML, Garcia K, et al. Genomic features of humoral immunity support tolerance model in Egyptian rousette batsexternal icon. Cell Rep. 2021 May 18;35(7):109140.
Bessières M, Plebanek E, Chatterjee P, et al. Design, synthesis and biological evaluation of 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles as inhibitors of Ebola virus infectionexternal icon. Eur J Med Chem. 2021 Mar 15;214:113211.
Obaidat MM, Graziano JC, Morales-Betoulle M, Brown SM, Chiang CF, Klena JD. Rift Valley Fever and Crimean-Congo Hemorrhagic Fever viruses in ruminants, Jordan. Emerg Infect Dis. 2021 Feb;27(2):653-655.
Guito JC, Prescott JB, Arnold CE, et al. Asymptomatic Infection of Marburg Virus Reservoir Bats Is Explained by a Strategy of Immunoprotective Disease Toleranceexternal icon. Curr Biol. 2021 Jan 25;31(2):257-270.e5.
Hoffmann HH, Schneider WM, Rozen-Gagnon K, et al. TMEM41B Is a Pan-flavivirus Host Factorexternal icon. Cell. 2021 Jan 7;184(1):133-148.e20. Rahman MZ, Islam MM, Hossain ME, et al. Genetic diversity of Nipah viruses in Bangladeshexternal icon. Int J Infect Dis. 2021 Jan;102:144-151.
Amman BR, Schuh AJ, Sealy TK, et al. Experimental infection of Egyptian rousette bats (Rousettus aegyptiacus) with Sosuga virus demonstrates potential transmission routes for a bat-borne human pathogenic paramyxovirusexternal icon. PLoS Negl Trop Dis. 2020 Mar 2;14(3):e0008092.
Lee KH, Nikolay B, Sazzad HMS, et al. Changing contact patterns over disease progression: Nipah virus as a case studyexternal icon. J Infect Dis. 2020 Mar 2:jiaa091.
Lo MK, Amblard F, Flint M, et al. Potent in vitro activity of β-D-4′-chloromethyl-2′-deoxy-2′-fluorocytidine against Nipah virusexternal icon. Antiviral Res. 2020 Mar;175:104712.
Welch SR, Tilston NL, Lo MK, et al. Inhibition of Nipah Virus by Defective Interfering Particlesexternal icon. J Infect Dis. 2020 Feb 28:jiz564.
Wozniak DM, Lavender KJ, Prescott J, Spengler JR. The Utility of Human Immune System Mice for High-Containment Viral Hemorrhagic Fever Researchexternal icon. Vaccines (Basel). 2020 Feb 22;8(1):E98.
Reichler MR, Bruden D, Thomas H. Ebola Patient Virus Cycle Threshold and Risk of Household Transmission of Ebola Virusexternal icon. J Infect Dis. 2020 Feb 18;221(5):707-714.
Lo MK, Spengler JR, Krumpe LRH, et al. Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challengeexternal icon. J Infect Dis. 2020 Feb 10:jiz630.
Zivcec M, Spiropoulou CF, Spengler JR. The use of mice lacking type I or both type I and type II interferon responses in research on hemorrhagic fever viruses. Part 2: Vaccine efficacy studiesexternal icon. Antiviral Res. 2020 Feb;174:104702.
McMullan LK. Clinical trials in an Ebola outbreak seek to find an evidence-based cureexternal icon. EBioMedicine. 2020 Feb;52:102614.
Amman BR, Bird BH, Bakarr IA, et al. Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africaexternal icon. Nat Commun. 2020 Jan 24;11(1):510.
Welch SR, Scholte FEM, Harmon JR, et al. Corrigendum to: In Situ Imaging of Fluorescent Nipah Virus Respiratory and Neurological Tissue Tropism in the Syrian Hamster Modelexternal icon. J Infect Dis. 2019 Dec 31:jiz627.
Dzimianski JV, Scholte FEM, Williams IL, et al. Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteasesexternal icon. PLoS One. 2019 Dec 23;14(12):e0226415.
Yadav PD, Mauldin MR, Nyayanit DA, et al. Isolation and phylogenomic analysis of buffalopox virus from human and buffaloes in Indiaexternal icon. Virus Res. 2019 Dec 9;277:197836.
Prescott J, Guito JC, Spengler JR, et al. Rousette Bat Dendritic Cells Overcome Marburg Virus-Mediated Antiviral Responses by Upregulation of Interferon-Related Genes While Downregulating Proinflammatory Disease Mediatorsexternal icon.. mSphere. 2019 Dec 4;4(6):e00728-19.
Welch SR, Ritter JM, McElroy AK, et al. Fluorescent Crimean-Congo Hemorrhagic Fever Virus Illuminates Tissue Tropism Patterns and Identifies Early Mononuclear Phagocytic Cell Targets in Ifnar -/-Miceexternal icon. PLoS Pathog, 15 (12). 2019 Dec 2;15(12):e1008183.
Wiley MR, Fakoli L, Letizia AG, et al. Lassa virus circulating in Liberia: a retrospective genomic characterisationexternal icon. Lancet Infect Dis. 2019 Dec;19(12):1371-1378.
Pickering BS, Spengler JR, Shadabi E, et al. The Biosafety Level 4 Zoonotic Laboratory Network (BSL4ZNet): Report of a workshop on live animal handlingexternal icon. Antiviral Res. 2019 Dec;172:104640.
Lo MK, Spengler JR, Welch SR, et al. Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein against Lethal Nipah virus Challenge in Syrian Hamstersexternal icon. J Infect Dis. 2019 Nov 21:jiz553.
Genzer SC, Welch SR, Scholte FEM, et al. Alterations in Blood Chemistry Levels Associated with Nipah Virus Disease in the Syrian Hamster Modelexternal icon. J Infect Dis. 2019 Nov 20:jiz552.
Satterfield BA, Borisevich V, Foster SL, et al. Antagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret modelexternal icon. Sci Rep. 2019 Nov 13;9(1):16710.
Welch SR, Scholte FEM, Harmon JR, et al. In Situ Imaging of Fluorescent Nipah Virus Respiratory and Neurological Tissue Tropism in the Syrian Hamster Modelexternal icon. J Infect Dis. 2019 Oct 30:jiz393.
Arunkumar G, Devadiga S, McElroy AK, et al. Adaptive Immune Responses in Humans During Nipah Virus Acute and Convalescent Phases of Infectionexternal icon. Clin Infect Dis. 2019 Oct 30;69(10):1752-1756.
Dzimianski JV, Scholte FEM, Bergeron É, Pegan SD. ISG15: It’s Complicatedexternal icon. J Mol Biol. 2019 Oct 4;431(21):4203-4216.
Spengler JR, Welch SR, Scholte FEM, et al. Heterologous Protection against Crimean-Congo Hemorrhagic Fever in Mice after a Single Dose of Replicon Particle Vaccineexternal icon. Antiviral Res. 2019 Oct;170:104573.
Shastri B, Kofman A, Hennenfent A, et al. Domestically Acquired Seoul Virus Causing Hemophagocytic Lymphohistiocytosis-Washington, DC, 2018external icon. Open Forum Infect Dis. 2019 Sep 21;6(10):ofz404.
Kainulainen MH, Spengler JR, Welch SR, et al. Protection from Lethal Lassa Disease Can Be Achieved Both Before and After Virus Exposure by Administration of Single-Cycle Replicating Lassa Virus Replicon Particlesexternal icon. J Infect Dis. 2019 Sep 13;220(8):1281-1289.
Yates MK, Chatterjee P, Flint M, et al. Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activityexternal icon. Molecules. 2019 Sep 2;24(17):3184.
Tramontano E, Tarbet B, Spengler JR, et al. Meeting report: 32nd International Conference on Antiviral Researchexternal icon. Antiviral Res. 2019 Sep;169:104550.
McMullan LK, Flint M, Chakrabarti A, et al. Characterisation of Infectious Ebola Virus from the Ongoing Outbreak to Guide Response Activities in the Democratic Republic of the Congo: A Phylogenetic and In Vitro Analysisexternal icon. Lancet Infect Dis. 2019 Sep;19(9):1023-1032.
Yadav PD, Shete AM, Nyayanit DA, et al. Corrigendum: Identification and characterization of novel mosquito-borne (Kammavanpettai virus) and tick-borne (Wad Medani) reoviruses isolated in Indiaexternal icon. J Gen Virol. 2019 Sep;100(9):1340.
Hegde ST, Salje H, Sazzad HMS, et al. Using healthcare-seeking behaviour to estimate the number of Nipah outbreaks missed by hospital-based surveillance in Bangladeshexternal icon. Int J Epidemiol. 2019 Aug 1;48(4):1219-1227.
Scholte FEM, Spengler JR, Welch SR, et al. Single-dose Replicon Particle Vaccine Provides Complete Protection Against Crimean-Congo Hemorrhagic Fever Virus in Miceexternal icon. Emerg Microbes Infect, 2019;8(1):575-578.
Scholte FEM, Hua BL, Spengler JR, et al. Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infectionexternal icon. mBio. 2019 Jul 23;10(4):e01065-19.
Abudurexiti A, Adkins S, Alioto D, et al. Taxonomy of the order Bunyavirales: update 2019external icon. Arch Virol. 2019 Jul;164(7):1949-1965.
Amarasinghe GK, Ayllón MA, Bào Y, et al. Taxonomy of the order Mononegavirales: update 2019external icon. Arch Virol. 2019 Jul;164(7):1967-1980.
Yadav PD, Whitmer SLM, Sarkale P, et al. Characterization of Novel Reoviruses Wad Medani Virus (Orbivirus) and Kundal Virus (Coltivirus) Collected from Hyalomma anatolicum Ticks in India during Surveillance for Crimean Congo Hemorrhagic Feverexternal icon. J Virol. 2019 Jun 14;93(13):e00106-19.
Spengler JR, Welch SR, Genzer SC, et al. Suboptimal Handling of Piccolo Samples or Reagent Discs for Consideration in Ebola Response. Emerg Infect Dis. 2019 Jun;25(6):1238-1240.
Fernando R, Capone D, Elrich S, et al. Infection with New York Orthohantavirus and Associated Respiratory Failure and Multiple Cerebral Complications. Emerg Infect Dis. 2019 Jun;25(6):1241-1243.
Kuhn JH, Amarasinghe GK, Basler CF, et al. ICTV Virus Taxonomy Profile: Filoviridaeexternal icon. J Gen Virol. 2019 Jun;100(6):911-912.
Davis CW, Jackson KJL, McElroy AK, et al. Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infectionexternal icon. Cell. 2019 May 30;177(6):1566-1582.e17.
Lo MK, Feldmann F, Gary JM, et al. Remdesivir (GS-5734) protects African green monkeys from Nipah virus challengeexternal icon. Sci Transl Med. 2019 May 29;11(494):eaau9242.
Spiropoulou CF. Nipah Virus Outbreaks: Still Small but Extremely Lethalexternal icon. J Infect Dis. 2019 May 24;219(12):1855-1857.
Rodriguez SE, Cross RW, Fenton KA, et al. Vesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Feverexternal icon. Sci Rep. 2019 May 23;9(1):7755.
Nikolay B, Salje H, Hossain MJ, et al. Transmission of Nipah Virus – 14 Years of Investigations in Bangladeshexternal icon. N Engl J Med. 2019 May 9;380(19):1804-1814.
Schuh AJ, Amman BR, Sealy TK, et al. Antibody-Mediated Virus Neutralization is Not a Universal Mechanism of Marburg, Ebola, or Sosuga Virus Clearance in Egyptian Rousette Batsexternal icon. J Infect Dis. 2019 May 5;219(11):1716-1721.
de St Maurice A, Harmon J, Nyakarahuka L, et al. Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestationsexternal icon. PLoS Negl Trop Dis. 2018 May 4;12(5):e0006460.
Gary JM, Welch SR, Ritter JM, et al. Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model. Emerg Infect Dis. 2019 May;25(5):865-874.
Genzer SC, Huynh T, Coleman-Mccray JD, et al. Hematology and Clinical Chemistry Reference Intervals for Inbred Strain 13/n Guinea Pigs (Cavia Porcellus)external icon. J Am Assoc Lab Anim Sci, 58 (3), 293-303. 2019 May.
Schuh AJ, Amman BR, Sealy TS, et al. Comparative Analysis of Serologic Cross-Reactivity Using Convalescent Sera from Filovirus – Experimentally Infected Fruit Batsexternal icon. Sci Rep, 9 (1), 6707. 2019 Apr 30;9(1):6707.
Bruhn JF, Hotard AL, Spiropoulou CF, et al. A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Functionexternal icon. Structure. 2019 Apr 2;27(4):660-668.e4.
Maes P, Amarasinghe GK, Ayllón MA, et al. Taxonomy of the order Mononegavirales: second update 2018external icon. Arch Virol. 2019 Apr;164(4):1233-1244.
Nyakarahuka L, Shoemaker TR, Balinandi S, et al. Marburg Virus Disease Outbreak in Kween District Uganda, 2017: Epidemiological and Laboratory Findingsexternal icon. PLoS Negl Trop Dis. 2019 Mar 18;13(3):e0007257.
Jones MEB, Amman BR, Sealy TK, et al. Clinical, Histopathologic, and Immunohistochemical Characterization of Experimental Marburg Virus Infection in A Natural Reservoir Host, the Egyptian Rousette Bat (Rousettus aegyptiacus)external icon. Viruses. 2019 Mar 2;11(3):214.
Malvy D, McElroy AK, de Clerck H, et al. Ebola virus diseaseexternal icon. Lancet. 2019 Mar 2;393(10174):936-948.
Fagre AC, Lee JS, Kityo RM, et al. Discovery and Characterization of Bukakata orbivirus (Reoviridae:Orbivirus), a Novel Virus from a Ugandan Batexternal icon. Viruses. 2019 Mar 2;11(3):209.
Shoemaker TR, Nyakarahuka L. Balinandi S, et al. First Laboratory – Confirmed Outbreak of Human Animal Rift Valley Fever Virus in Uganda in 48 Yearsexternal icon. Am J Trop Med Hyg, 2019 Mar;100(3):659-671.
Maes P, Adkins S, Alkhovsky SV, et al. Taxonomy of the order Bunyavirales: second update 2018external icon. Arch Virol. 2019 Mar;164(3):927-941.
Liu WJ, Sesay FR, Coursier A, et al. Comprehensive Clinical and Laboratory Follow-up of a Female Patient With Ebola Virus Disease: Sierra Leone Ebola Virus Persistence Studyexternal icon. Open Forum Infect Dis. 2019 Feb 26;6(3):ofz068.
Spengler JR, Bergeron É, Spiropoulou CF et al. Crimean-Congo Hemorrhagic Fever and Expansion from Endemic Regionsexternal icon. Curr Opin Viro. 2019 Feb;34:70-78.
Kofman A, Choi MJ, Rollin PE. Lassa Fever in Travelers from West Africa, 1969-2016. Emerg Infect Dis. 2019 Feb;25(2):245-248.
McElroy AK, Shrivastava-Ranjan P, Harmon JR, et al. Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans. Emerg Infect Dis. 2019 Feb;25(2):290-298.
Flint M, Chatterjee P, Lin DL, et al. A Genome-Wide CRISPR Screen Identifies N-acetylglucosamine – 1-phosphate Transferase as a Potential Antiviral Target for Ebola Virusexternal icon. Nat Commun. 2019 Jan17;10(1):285.
Dzimianski JV, Beldon BS, Daczkowski CM, et al. Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activityexternal icon. PLoS Pathog. 2019 Jan 10;15(1):e1007515.