Frequestly Asked Questions
What is nanotechnology? Where did it come from, and how long has it been around?
- Research and technology development involves structures with at least one dimension in the 1-100 nanometer range.
- Creating and using structures, devices and systems that have new properties and functions because of their nanometer scale dimensions.
- Ability to control or manipulate on the atomic scale.
Nanostructured materials do not represent a new phenomenon. For example, the red and yellow hues in stained glass are the result of the presence of nanometer-sized gold and silver particles. However, the ability to probe, manipulate, understand and engineer matter at atomic scales has only recently become possibility In a 1959 lecture titled “There’s plenty of room at the bottom”, the Nobel laureate Professor Richard P. Feynman introduced the idea of a new and exciting field of research based on manipulating matter at the atomic level. At the time, Professor Feynman’s predictions were based on theoretical speculation. However, developments such as the invention of the Scanning Tunneling Microscope in 1981 have since made nanoscale science a reality. Nanotechnology is now a rapidly growing field of research and development that is cutting across many traditional boundaries.
Where can I find more information about NIOSH’s research pertaining to occupational health and nanotechnology? Where can I find additional information about the National Nanotechnology Initiative (NNI)?
More information on NIOSH’s nanotechnology research program can be found at the NIOSH Nanotechnology topic page. This is designed to be a robust source of information on NIOSH’s research program, with new information added as it becomes available. Additional information can be found on the National Nanotechnology Initiative (NNI) website.
What kinds of nanomaterials (nanoproducts) are in production or use in the U.S.?
An increasing number of products and materials are becoming commercially available. These include nanoscale powders, solutions, suspensions as well as composite materials and devices containing nanomaterials. Nanoscale titanium dioxide is currently used in cosmetics, sun block creams and self-cleaning windows. Nanomaterials are increasingly being used in optoelectronic, electronic, magnetic, medical imaging, drug delivery, cosmetic, catalytic, and other applications. Nano-coatings and nano-composites are being used in a wide range of consumer products from bicycles to automobiles. Further details on existing products can be found at http://www.nano.gov/you/nanotechnology-benefits
Why is NIOSH conducting research on nanotechnology and occupational health?
- Are workers exposed to nanomaterials in the manufacture and use of nanomaterials, and if so what are the characteristics and levels of exposures?
- Are there potential adverse health effects of working with nanomaterials?
- What work practices, personal protective equipment, and engineering controls are available, and how effective are they for controlling exposures to nanomaterials?
NIOSH is addressing these questions through a program of multi-disciplinary research, communication, and partnerships with other agencies, organizations, and stakeholders.
What knowledge or expertise does NIOSH bring to this research?
NIOSH’s research role stems from its mission as the federal institute that conducts research and makes recommendations in occupational safety and health. For more than 40 years, NIOSH has led research to define and address occupational health concerns related to emerging technologies and workplace practices. To its research on nanotechnology and occupational health, NIOSH brings:
- Experience in defining the characteristics and properties of ultrafine particles (such as welding fume and diesel particulate), which have some features in common with engineered nanomaterials.
- Capability of conducting laboratory studies to determine advanced health effects laboratory studies.
- Historic leadership in industrial hygiene policies and practices.
- Close research partnerships with diverse stakeholders in industry, labor, the government, and academia.
How does NIOSH relate to other government efforts associated with research and development in nanotechnology?
How many workers are potentially exposed to nanoparticles?
Roco MC, Mirkin CA, Hersam MC  Nanotechnology research directions for societal needs in 2020: retrospective and outlook. Arlington, VA: National Science Foundation [http://wtec.org/nano2/].
How may workers be exposed to nanoparticles?
What effects do nanomaterials have on workers’ health?
- Asbestos and carbon nanotubes (CNTs) affect similar molecular signaling pathways in cultured lung cells, with asbestos exhibiting greater potency
- Nano or ultrafine titanium dioxide (TiO2) causes pulmonary inflammation and neuro-immune responses
- Ultrafine TiO2 or carbon black causes more inflammation than fine TiO2 or carbon black on a mass-dose basis
- Dispersion of ultrafine carbon black nanoparticles in the lungs of rats following intratracheal instillation results in an inflammatory response that is greater than agglomerated ultrafine carbon black
- Pulmonary exposure to single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) in mice causes acute and chronic systemic responses associated with adverse cardiovascular effects
- SWCNTs, MWCNTs, and carbon nanofibers (CNFs) have equal or greater potency in causing adverse health effects in laboratory animals, including pulmonary inflammation and fibrosis, in comparison with other inhaled particles (ultrafine TiO2, carbon black, crystalline silica, and asbestos)
- CNTs are genotoxic and can transform lung epithelial cells after long-term, low-dose in vitro exposure
- Preliminary research has indicated that mice exposed to both MWCNTs and methylcholanthrene (a known cancer initiator) are significantly more likely to develop tumors than those exposed to just MWCNT alone. See NIOSH Science Blog.
How should workplace exposures to nanomaterials be measured?
Exposure assessment and control verification approaches can be performed with traditional industrial hygiene sampling methods that include the use of samplers placed at static locations (area sampling), samples collected in the breathing zone of the employee (personal sampling), and measurements with real-time direct reading instrumentation. An integrated sampling strategy should include the use of both direct reading instrumentation and filter-based samples. Direct-reading instrumentation can be used to data log particle concentrations Filter-based samples can be used to identify the nanomaterial of interest with electron microscopy and elemental analysis.
Should workplace exposures be controlled and if so, how?
What are potential applications of nanotechnology in occupational safety and health?
- National Institute for Occupational Safety and Health (NIOSH)
- Centers for Disease Control and Prevention
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