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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Naphthalene

CAS number: 91–20–3

NIOSH REL: 10 ppm (50 mg/m3) TWA, 15 ppm (75 mg/m3) STEL

Current OSHA PEL: 10 ppm (50 mg/m3) TWA

1989 OSHA PEL: 10 ppm (50 mg/m3) TWA, 15 ppm (75 mg/m3) STEL

1993-1994 ACGIH TLV: 10 ppm (52 mg/m3) TWA, 15 ppm (79 mg/m3) STEL

Description of substance: Colorless to brown solid with an odor of mothballs.

LEL: . . . 0.9% (10% LEL, 900 ppm)

Original (SCP) IDLH: 500 ppm

Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for naphthalene. The chosen IDLH, therefore, has been estimated from the probable oral lethal dose of 5 to 15 grams for an adult [Gerarde 1960 cited by AIHA 1967].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

 

SpeciesReferenceRouteLD50

(mg/kg)

LDLo

(mg/kg)

Adjusted LDDerived value
Rat

Rat

G. pig

Mouse

Gosselin et al. 1984

Izmerov et al. 1982

Matorova 1982

Shopp et al. 1984

oral

oral

oral

oral

1,800

490

1,200

533

-----

-----

-----

-----

2,355 ppm

641 ppm

1,570 ppm

697 ppm

236 ppm

64 ppm

157 ppm

70 ppm

Human data: The probable oral lethal dose has been reported to be between 5 and 15 grams [Gerarde 1960]. [Note: An oral dose between 5 and 15 grams is equivalent to a worker being exposed to about 600 to 1,800 ppm for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]


 

Revised IDLH: 250 ppm

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for naphthalene. Therefore, the revised IDLH for naphthalene is 250 ppm based on acute oral toxicity data in humans [Gerarde 1960].

REFERENCES:

1. AIHA [1967]. Naphthalene. In: Hygienic guide series. Am Ind Hyg Assoc J 28:493-496.

2. Gerarde HW [1960]. Toxicology and biochemistry of aromatic hydrocarbons. Princeton, NJ: Elsevier Publishing Company, p. 228.

3. Gosselin RE, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Section III. Therapeutics Index. Baltimore, MD: Williams & Wilkins Company, pp. 307-310.

4. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 89.

5. Matorova NI [1982]. Data on establishing the maximum permissible concentration of naphthalene and chloronaphthalene in reservoir water. Gig Sanit 11:78-79 (in Russian).

6. Shopp GM, White KL Jr, Holsapple MP, Barnes DW, Duke SS, Anderson AC, Condie LW, Hayes JR, Borzelleca JF [1984]. Naphthalene toxicity in CD-1 mice: general toxicology and immunotoxicology. Fundam Appl Toxicol 4:406-419.

 
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