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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Nitrotoluene (o-, m-, p-isomers)

CAS numbers: 88-72-2 (o-isomer), 99-08-1 (m-isomer), 99-99-0 (p-isomer)

NIOSH REL: 2 ppm (11 mg/m3) TWA [skin]

Current OSHA PEL: 5 ppm (30 mg/m3) TWA [skin]

1989 OSHA PEL: 2 ppm (11 mg/m3) TWA [skin]

1993-1994 ACGIH TLV: 2 ppm (11 mg/m3) TWA [skin]

Description of substance: Yellow liquids (o-, m-isomers) or a crystalline solid (p-isomer) with weak, aromatic odors.

LEL(o-isomer): 2.2% (10% LEL, 2,200 ppm)

Original (SCP) IDLH: 200 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with nitrobenzene which has an IDLH of 200 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

 

SpeciesReferenceRouteLD50

(mg/kg)

LDLo

(mg/kg)

Adjusted

LD

Derived value
o-isomer RatVasilerko et al. 1978 oral891-----1,094 ppm109 ppm
o-isomer MouseVasilerko et al. 1978 oral970-----1,191 ppm119 ppm
o-isomer RabbitVasilerko et al. 1978 oral1,750-----2,149 ppm215 ppm
p-isomer MouseBack et al. 1972 oral1,231-----1,512 ppm151 ppm
p-isomer RatVasilerko et al. 1978 oral1,960-----2,407 ppm241 ppm
p-isomer RabbitVasilerko et al. 1978 oral1,750 -----2,149 ppm215 ppm

Human data: It has been stated that nitrotoluene is only slightly toxic, especially in comparison with nitrobenzene [Linch 1974].

 

Revised IDLH: 200 ppm [Unchanged]

Basis for revised IDLH: Based on acute oral toxicity data in animals [Back et al. 1972; Vasilerko et al. 1978] and an analogy to nitrobenzene [Linch 1974] which has an IDLH of 200 ppm, the original IDLH for nitrotoluene (200 ppm) is not being revised at this time.

REFERENCES:

1. Back KC, Thomas AA, MacEwen JD [1972]. Reclassification of materials listed as transportation health hazards. Wright-Patterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA-20-72-3, pp. A-310 to A-311.

2. Linch AL [1974]. Biological monitoring for industrial exposure to cyanogenic aromatic nitro and amino compounds. Am Ind Hyg Assoc J 35:426-432.

3. Vasilerko NM, Kovalenko EE, Batuzina TS [1978]. Experimental substantiation of hygienic concentrations of isomers of mononitrotoluenes in the air of the working zone. Gig Tr Prof Zabol 22(7):52 (in Russian).

 
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