Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 78–93–3
NIOSH REL: 200 ppm (590 mg/m3) TWA, 300 ppm (885 mg/m3) STEL
Current OSHA PEL: 200 ppm (590 mg/m3) TWA
1989 OSHA PEL: 200 ppm (590 mg/m3) TWA, 300 ppm (885 mg/m3) STEL
1993-1994 ACGIH TLV: 200 ppm (590 mg/m3) TWA, 300 ppm (885 mg/m3) STEL
Description of Substance: Colorless liquid with a moderately sharp, fragrant, mint- or acetone-like odor.
LEL(@200EF): 1.4% (10% LEL(@200EF), 1,400 ppm)
Original (SCP) IDLH: 3,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty  that a 2-hour exposure of rats to 2,000 ppm caused no deaths, but 4 of 6 rats exposed to 4,000 ppm for a 2-hour period died [Smyth 1956].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Esin and Vigdergauz 1986|
Izmerov et al. 1982
Pozzani et al. 1959
21,333 ppm (1.6)
19,583 ppm (2.5)
6,400 ppm (1.6)
Lethal dose data:
|Kimura et al. 1971|
Tanii et al. 1986
Human data: It has been reported that 3,000 ppm is
irritating to the eyes and nose [Patty et al. 1935].
|Revised IDLH: 3,000 ppm [Unchanged]
Basis for revised IDLH: Based on acute inhalation toxicity data in humans [Patty et al. 1935], the original IDLH for 2-butanone (3,000 ppm) is not being revised at this time.
1. Esin MS, Vigdergauz MS . Correlation between toxicity indexes and chromatographic characteristics of chemical substances. Gig Sanit 51(5):61-62 (in Russian).
2. Izmerov NF, Sanotsky IV, Sidorov KK . Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 83.
3. Kimura ET, Ebert DM, Dodge PW . Acute toxicity and limits of solvent residue for sixteen organic solvents. Toxicol Appl Pharmacol 19:699-704.
4. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1733.
5. Patty FA, Schrenk HH, Yant WP . Acute response of guinea pigs to vapors of some new commercial organic compounds. VIII. Butanone. Public Health Rep 50:1217-1228.
6. Pozzani UC, Weil CS, Carpenter CP . The toxicological basis of threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am Ind Hyg Assoc J 20:364-369.
7. Smyth HF Jr . Improved communication: hygienic standards for daily inhalation. Am Ind Hyg Assoc Q 17(2):129-185.
8. Tanii H, Tsuji H, Hashimoto K . Structure-toxicity
relationship of monoketones. Toxicol Lett 30:13-17.
- National Institute for Occupational Safety and Health (NIOSH)
- Centers for Disease Control and Prevention
TTY: (888) 232-6348
- New Hours of Operation
- Contact CDC-INFO