Tetraethyl lead (as Pb)
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 78–00–2
NIOSH REL: 0.075 mg/m3 TWA [skin]
Current OSHA PEL: 0.075 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.1 mg/m3 TWA [skin]
Description of substance: Colorless liquid (unless dyed red, orange, or blue) with a pleasant, sweet odor.
LEL: . . 1.8% (10% LEL, 1,800 ppm)
Original (SCP) IDLH: 40 mg Pb/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the rat LC50 of 6 ppm (approximately 80 mg/m3) [Saglik Dergisi 1963 cited by NIOSH 1974]. However, because of the unreliability of tetraethyl lead analytical methods utilized prior to 1968, 40 mg Pb/m3, which is approximately 50% of the LC50, has been utilized as the IDLH.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Species||Reference||LC50||LCLo||Time||Adjusted 0.5-hr |
|Mouse||Akatsuka 1973||-----||650 mg/m3||7 hr||999 mg Pb/m3 (2.4)||100 mg Pb/m3|
|Rat||Cremer & Calloway 1961||850 mg/m3||-----||1 hr||680 mg Pb/m3 (1.25)||68 mg Pb/m3|
Lethal dose data:
|Adjusted LD||Derived value|
|Akatsuka 1973 |
Magistretti et al. 1963
Schroeder et al. 1972
Springman et al. 1963
|135 mg Pb/m3 |
157 mg Pb/m3
76 mg Pb/m3
55 mg Pb/m3
108 mg Pb/m3
|14 mg Pb/m3 |
16 mg Pb/m3
7.6 mg Pb/m3
5.5 mg Pb/m3
11 mg Pb/m3
Human data: It has been stated that 100 mg Pb/m3 for 1 hour may produce illness [Fleming 1963].
|Revised IDLH: 40 mg Pb/m3 [Unchanged] |
Basis for revised IDLH: Based on acute inhalation toxicity data in humans [Fleming 1963] and animals [Akatsuka 1973; Cremer and Calloway 1961], a value of about 100 mg Pb/m3 would have been appropriate for tetraethyl lead. However, the original IDLH for tetraethyl lead (40 mg Pb/m3) is not being revised at this time.
1. Akatsuka K . Tetraalkyl lead poisoning. Sangyo Igaku (Japanese Journal of Industrial Health) 15:3-66.
2. Cremer JE, Calloway S . Further studies on the toxicity of some tetra and trialkyl lead compounds. Brit J Ind Med 18:277-282.
3. Fleming AJ . Lead Symposium, Kettering Laboratory, University of Cincinnati, February 25-27, 1963.
4. Magistretti M, Zurlo N, Scollo F, Pacillo D . Tossicita comparata del piombo tetra-etile e del piombo tetra-metile. Med Lav 54:486-495 (in Italian).
5. NIOSH . TP45500. Plumbane, tetraethyl-. In: The toxic substances list, 1974 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 74-134, p. 634.
6. Saglik Dergisi ; 38:653.
7. Schepers GWH . Tetraethyl lead and tetramethyl lead comparative experimental pathology: Part I. Lead absorption and pathology. Arch Environ Health 8:277-295.
8. Schroeder T, Avery DD, Cross HA . Tetraethyl lead dose response curve for mortality in laboratory rats. Experientia 28:923-924.
9. Springman E, Bingham E, Stemmer KL . The acute effects of lead alkyls. Arch Environ Health 6:469.
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