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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Nitrogen trifluoride

CAS number: 7783–54–2

NIOSH REL: 10 ppm (29 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

Current OSHA PEL: 10 ppm (29 mg/m3) TWA

1993-1994 ACGIH TLV: 10 ppm (29 mg/m3) TWA

Description of substance: Colorless gas with a moldy odor.

LEL: . Nonflammable Gas

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC50 of 2,000 ppm cited by Deichmann and Gerarde [1969]. Deichmann and Gerarde [1969] also stated that nitrogen trifluoride is a pulmonary irritant comparable in toxicity to the oxides of nitrogen.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

 

SpeciesReferenceLC50

(ppm)

LCLo

(ppm)

TimeAdjusted 0.5-hr

LC (CF)

Derived value
MouseDeichmann & Gerarde 1969 2,000-----4 hr4,000 ppm (2.0)400 ppm
DogMacEwen & Vernot 1969 9,600-----1 hr12,000 ppm (1.25)1,200 ppm
MonkeyMacEwen & Vernot 1969 7,500-----1 hr9,375 ppm (1.25)938 ppm
RatVernot et al. 1973 6,700-----1 hr8,375 ppm (1.25)838 ppm
MouseVernot et al. 1973 7,500-----1 hr9,375 ppm (1.25)938 ppm

Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 1,000 ppm

Basis for revised IDLH: The revised IDLH for nitrogen trifluoride is 1,000 ppm based on acute inhalation toxicity data in animals [MacEwen and Vernot 1969; Vernot et al. 1973].

REFERENCES:

1. Deichmann WB, Gerarde HW [1969]. Nitrogen trifluoride. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 427.

2. MacEwen JD, Vernot EH [1969]. Toxic Hazards Research Unit annual technical report: 1969. Wright-Patterson Air Force Base, OH: Aerospace Medical Research Laboratory, Report AMRL-TR-69-84, pp. 1-49.

3. Vernot EH, Haun CC, MacEwen JD, Egan GF [1973]. Acute inhalation toxicology and proposed emergency exposure limits of nitrogen trifluoride. Toxicol Appl Pharmacol 26:1-13.

 
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