Description of substance: Colorless to white crystalline, odorless
solid.
LEL: Noncombustible Solid
Original (SCP) IDLH: 5,000 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the rat
intraperitoneal LDLO of 800 mg/kg cited by
NIOSH [1976] from Ambrose [1943]. This
compound has a low toxicity.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
Species
Reference
Route
LD50(mg/kg)
LDLo(mg/kg)
Adjusted LD
Derived Value
Rat
Ball 1956
oral
2,000
-----
14,000 mg/m3
1,400 mg/m3
Mouse
Gig Tr Prof Zabol 1963
oral
3,100
-----
21,700 mg/m3
2,170 mg/m3
Rat
Lehman 1951
oral
3,900
-----
27,300 mg/m3
2,730 mg/m3
Mouse
Lehman 1951
oral
5,760
-----
40,320 mg/m3
4,032 mg/m3
Human data: None relevant for use in determining the
revised IDLH.
Revised IDLH: 1,500 mg/m3
Basis for revised IDLH: No inhalation toxicity data are available on which to
base an IDLH for ammonium sulfamate. Therefore, the revised IDLH for ammonium
sulfamate is 1,500 mg/m3 based on the acute oral toxicity data in animals
[Ball 1956]. This may be a conservative value due to the lack of relevant
acute toxicity data for workers.
REFERENCES:
Ambrose AM [1943]. Studies of the physiological effects of sulfamic acid
and ammonium sulfamate. J Ind Hyg Toxicol 25:26.
Ball WL [1956]. Threshold limits for pesticides. AMA Arch Ind Health
14:178-185.
Gig Tr Prof Zabol [1963]; 7(5):56-57 (in Russian).
Lehman AJ [1951]. Chemicals in foods: a report to the Association of Food
and Drug Officials on current developments. Part II. Pesticides. Q Bulletin
Assoc Food Drug Off U.S. 15(4):122-125.
NIOSH [1976]. WO61250. Sulfamic acid, monoammonium salt. In: Registry
of Toxic Effects of Chemical Substances (RTECS) 1976 ed. Cincinnati, OH:
U.S. Department of Health, Education, and Welfare, Public Health Service,
Center for Disease Control, National Institute for Occupational Safety and
Health, DHEW (NIOSH) Publication No. 76-191, p. 1111.
