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May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

Camphor (synthetic)

CAS number: 76–22–2

NIOSH REL: 2 mg/m3 TWA

Current OSHA PEL: 2 mg/m3 TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 12 mg/m3 (2 ppm) TWA, 19 mg/m3 (3 ppm) STEL

Description of Substance: Colorless or white crystals with a penetrating, aromatic odor.

LEL: . . 0.6% (10% LEL, 3,600 mg/m3)

Original (SCP) IDLH: 200 mg/m3

Basis for original (SCP) IDLH: No data on acute inhalation toxicity are available on which to base an IDLH for camphor. For this draft technical standard, therefore, the chosen IDLH is based on a report by Gronka et al. [1969] concerning the camphor processing and packaging area of a plant. Concentrations of camphor ranging from 3 to 194 mg/m3 produced nose and sinus irritation among workers in this plant [Gronka et al. 1969].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference

LC50

LCLo

Time
Adjusted 0.5-hr

LC (CF)

Derived

Value

MouseNikolaeva 1957-----400 mg/m33 hr720 mg/m3 (1.8)72 mg/m3


Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
Dog

Mouse

Rabbit

Flury and Zernik 1935

Horikawa and Okada 1975

Smith and Margolis 1954

oral

oral

oral

-----

1,310

-----

800

-----

2,000

5,600 mg/m3

9,170 mg/m3

14,000 mg/m3

560 mg/m3

917 mg/m3

1,400 mg/m3


Human data: It has been reported that concentrations during camphor processing and packaging ranged from 33 to 194 mg/m3; workers had no complaints other than slight eye irritation and afternoon drowsiness [Gronka et al. 1969].

 

Revised IDLH: 200 mg/m3 [Unchanged]

Basis for revised IDLH: Based on chronic inhalation toxicity data in workers [Gronka et al. 1969], the original IDLH for synthetic camphor (200 mg/m3) is not being revised at this time.


REFERENCES:

1. Flury F, Zernik F [1935]. Zusammenstellung der toxischen und letalen dosen für die gebräuchlichsten gifte und versuchstiere. Abder Hand Biol Arbeitsmethod 4:1289-1422 (in German).

2. Gronka PA, Bobkoski RL, Tomchick GJ, Rakow AB [1969]. Camphor exposures in a packaging plant. Am Ind Hyg Assoc J 30:276-279.

3. Horikawa E, Okada T [1975]. Experimental study on acute toxicity of phenol camphor. Shika Gakuho (Journal of Dentistry) 75:934-939 (in Japanese).

4. Nikolaeva [1957]. Toxicological evaluation of camphor vapors. Gig Sanit 22(11):83-86 (in Russian).

5. Smith AG, Margolis G [1954]. Camphor poisoning: anatomical and pharmacologic study; report of a fatal case; experimental investigation of protective action of barbiturate. Am J Pathol 30(5):857-868.

 
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