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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Perchloryl fluoride

CAS number: 7616–94–6

NIOSH REL: 3 ppm (14 mg/m3) TWA, 6 ppm (28 mg/m3) STEL

Current OSHA PEL: 3 ppm (13.5 mg/m3) TWA

1989 OSHA PEL: 3 ppm (14 mg/m3) TWA, 6 ppm (28 mg/m3) STEL

1993-1994 ACGIH TLV: 3 ppm (13 mg/m3) TWA, 6 ppm (25 mg/m3) STEL

Description of substance: Colorless gas with a characteristic, sweet odor.

LEL: . . Nonflammable Gas

Original (SCP) IDLH: 385 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the rat 4-hour LC50 of 385 ppm [Greene et al. 1960 cited by ACGIH 1971].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

 

SpeciesReferenceLC50 (ppm)LCLo (ppm)TimeAdjusted 0.5-hr LC (CF)Derived value
Rat

Rat

Mouse

Dog

Dost et al. 1974

Greene et al. 1960

Greene et al. 1960

Jacobson 1958

-----

385

630

-----

2,000

-----

-----

451

40 min

4 hr

4 hr

4 hr

2,200 ppm (1.1)

770 ppm (2.0)

1,260 ppm (2.0)

902 ppm (2.0)

220 ppm

77 ppm

126 ppm

90 ppm

Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 100 ppm

Basis for revised IDLH: The revised IDLH for perchloryl fluoride is 100 ppm based on acute inhalation toxicity data in animals [Greene et al. 1960; Jacobson 1958].

REFERENCES:

1. ACGIH [1971]. Perchloryl fluoride. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 202-203.

2. Dost FN, Reed DJ, Smith VN, Wang CH [1974]. Toxic properties of chlorine trifluoride. Toxicol Appl Pharmacol 27:527-536.

3. Greene EA, Colbourn JL, Donati E, Weeks MH [1960]. The inhalation toxicity of perchloryl fluoride. Army Chemical Center, Maryland: U.S. Army Chemical Research and Development Laboratories, Technical Report No. CRDLR 3010, p. 9.

4. Jacobson KH [1958]. Transactions of the Symposium on Health Hazards of Military Chemicals. Army Chemical Center, MD: Directorate of Medical Research, U.S. Army Chemical Warfare Laboratories, CWL Special Publication 2-10.

 
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