Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
Share
Compartir
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


tert-Butyl alcohol

CAS number: 75–65–0

NIOSH REL: 100 ppm (300 mg/m3) TWA, 150 ppm (450 mg/m3) STEL

Current OSHA PEL: 100 ppm (300 mg/m3) TWA

1989 OSHA PEL: 100 ppm (300 mg/m3) TWA, 150 ppm (450 mg/m3) STEL

1993-1994 ACGIH TLV: 100 ppm (303 mg/m3) TWA

Description of Substance: Colorless solid or liquid (above 77 F) with a camphor-like odor.

LEL: . . 2.4% (10% LEL, 2,400 ppm)

Original (SCP) IDLH: 8,000 ppm

Basis for original (SCP) IDLH: No data on acute inhalation toxicity are available on which to base the IDLH for tert-butyl alcohol, but Patty [1963] reported that the signs of intoxication on the part of animals exposed to its vapors are similar to those induced by the other butyl alcohols [Weese 1928]. For this draft technical standard, therefore, the IDLH is based on an analogy with isobutyl alcohol and n-butyl alcohol, which have IDLHs of 8,000 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
Rabbit

Rat

Munch 1972

Schaffarzick and Brown 1952

oral

oral

3,559

3,500

-----

-----

8,089 ppm

7,955 ppm

809 ppm

796 ppm


Other animal data: It has been reported that inhalation toxicity for tert-butyl alcohol is similar to that induced by the other butyl alcohols [Weese 1928].

Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 1,600 ppm

Basis for revised IDLH: The revised IDLH for tert-butyl alcohol is 1,600 ppm based on analogies [Weese 1928] to isobutyl alcohol and n-butyl alcohol.


REFERENCES:

1. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg 41:31-33.

2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1447.

3. Schaffarzick RW, Brown BJ [1952]. The anticonvulsant activity and toxicity of methylparafynol (Dormison®) and some other alcohols. Science 116:663-665.

4. Weese H [1928]. Comparative studies of the effect of toxicity of lower aliphatic alcohol vapors (translated). Arch Exp Pathol Pharmakol 135:121-123.

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO