Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Propylene imine

CAS number: 75–55–8

NIOSH REL: 2 ppm (5 mg/m3) TWA [skin]; NIOSH considers propylene imine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 2 ppm (5 mg/m3) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 2 ppm (4.7 mg/m3) TWA [skin], A2

Description of substance: Colorless, oily liquid with an ammonia-like odor.

LEL: . Unknown

Original (SCP) IDLH: 500 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Patty [1963] that 5 of 6 rats died from a 4-hour exposure to 500 ppm and 3 of 5 guinea pigs died from a 2-hour exposure to 500 ppm; at 500 ppm, rats survived a 2-hour exposure, and guinea pigs survived a 30-minute exposure [Carpenter et al. 1948].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

 

SpeciesReferenceLC50

(ppm)

LCLo

(ppm)

TimeAdjusted 0.5-hr

LC (CF)

Derived value
Rat

G. pig

G. pig

G. pig

Rat

Carpenter et al. 1949

Carpenter et al. 1948

Carpenter et al. 1948

Carpenter et al. 1948

Carpenter et al. 1948

-----

LC17 : 500

LC60 : 500

LC100: 500

LC83 : 500

500

-----

-----

-----

-----

4 hr

1 hr

2 hr

4 hr

4 hr

1,000 ppm (2.0)

625 ppm (1.25)

800 ppm (1.6)

1,000 ppm (2.0)

1,000 ppm (2.0)

100 ppm

63 ppm

80 ppm

100 ppm

100 ppm

Other animal data: It has been reported that rats survived a 2-hour exposure to 500 ppm and guinea pigs survived a 30-minute exposure to 500 ppm [Carpenter et al. 1948].

Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 100 ppm

Basis for revised IDLH: The revised IDLH for propylene imine is 100 ppm based on acute inhalation toxicity data in animals [Carpenter et al. 1948, 1949]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for propylene imine at concentrations above 2 ppm.]

REFERENCES:

1. Carpenter CP, Smyth HF Jr, Pozzani UC [1949]. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol 31:343-346.

2. Carpenter CP, Smyth HF Jr, Shaffer CB [1948]. The acute toxicity of ethylene imine to small animals. J Ind Hyg Toxicol 30:2-6.

3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2175.

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO