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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Ethylamine

CAS number: 75–04–7

NIOSH REL: 10 ppm (18 mg/m3) TWA

Current OSHA PEL: 10 ppm (18 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 5 ppm (9.2 mg/m3) TWA, 15 ppm (27.6 mg/m3) STEL

Description of Substance: Colorless gas or water-white liquid (below 62 F) with an ammonia-like odor.

LEL:. . 3.5% (10% LEL, 3,500 ppm)

Original (SCP) IDLH: 4,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1958] report that a 4-hour exposure to 4,000 ppm killed 1 of 6 rats.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived

value

Rat

Mammal

Rat

Hine et al. 1960

Kulagina 1975

UCC 1958

-----

1,230

-----

3,000

-----

4,000

4 hr

?

4 hr

6,000 ppm (2.0)

?

8,000 ppm (2.0)

600 ppm

?

800 ppm


Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
RatUCC 1958oral400-----1,497 ppm150 ppm


Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 600 ppm

Basis for revised IDLH: The revised IDLH for ethylamine is 600 ppm based on acute inhalation toxicity data in animals [Hine et al. 1960; UCC 1958].


REFERENCES:

1. Hine CH, Kodama JK, Guzman RJ, Loquvam GS [1960]. The toxicity of allylamines. Arch Environ Health 1:343-352.

2. Kulagina NK [1975]. Dependence of biological activity of aliphatic hydrocarbons on their chemical structure and physical-chemical properties. Toksikol Nov Prom Khim Vesh 14:80-90 (in Russian).

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

4. UCC [1958]. Toxicology studies: ethyl amine. New York, NY: Union Carbide Corporation.

 
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