May 1994

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)

Ethylamine

CAS number: 75–04–7

NIOSH REL: 10 ppm (18 mg/m³) TWA

Current OSHA PEL: 10 ppm (18 mg/m³) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 5 ppm (9.2 mg/m³) TWA, 15 ppm (27.6 mg/m³) STEL

Description of Substance: Colorless gas or water-white liquid (below 62 F) with an ammonia-like odor.

LEL:. . 3.5% (10% LEL, 3,500 ppm)

Original (SCP) IDLH: 4,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1958] report that a 4-hour exposure to 4,000 ppm killed 1 of 6 rats.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species

Reference

LC₅₀

(ppm)

LC_Lo

(ppm)

Time

Adjusted 0.5-hr

LC (CF)

Derived

value

Rat

Mammal

Rat

Hine et al. 1960

Kulagina 1975

UCC 1958

-----

1,230

-----

3,000

-----

4,000

4 hr

6,000 ppm (2.0)

8,000 ppm (2.0)

600 ppm

800 ppm

Lethal dose data:

Species	Reference	Route	LD₅₀ (mg/kg)	LD_Lo (mg/kg)	Adjusted LD	Derived value
Rat	UCC 1958	oral	400	-----	1,497 ppm	150 ppm

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 600 ppm

Basis for revised IDLH: The revised IDLH for ethylamine is 600 ppm based on acute inhalation toxicity data in animals [Hine et al. 1960; UCC 1958].

REFERENCES:

1. Hine CH, Kodama JK, Guzman RJ, Loquvam GS [1960]. The toxicity of allylamines. Arch Environ Health 1:343-352.

2. Kulagina NK [1975]. Dependence of biological activity of aliphatic hydrocarbons on their chemical structure and physical-chemical properties. Toksikol Nov Prom Khim Vesh 14:80-90 (in Russian).

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

4. UCC [1958]. Toxicology studies: ethyl amine. New York, NY: Union Carbide Corporation.