Cadmium compounds (as Cd)

CAS number: 7440–43–9 (Metal)

NIOSH REL: None established; NIOSH considers cadmium compounds to be potential occupational carcinogens as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 0.005 mg/m³ TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.01 mg/m³ (total dust) TWA,

0.002 mg/m³ (respirable dust) TWA, A2

Description of Substance: Varies

Original (SCP) IDLH for cadmium dust: 50 mg Cd/m³

Basis for original (SCP) IDLH: Data on the dose-response relationship for cadmium are scarce and uncertain. Friberg et al. [1974] reported a rabbit 30-minute LC₅₀ of about 8,000 mg-min/m³ (mg-min/m³ is the product of the concentration in mg/m³ and the exposure time in minutes); this represents a concentration of about 266 mg/m³ for 30 minutes. As serious irreversible renal cortical changes can precede death when renal cortical concentrations exceed 0.4 mg/g (tissue wet-weight), an IDLH of 50 mg/m³ is appropriate. This concentration would result in a human lung cadmium burden in 30 minutes of no more than 8 or 9 mg. This concentration is approximately that at which incipient morphologic changes occur in the kidneys of cadmium-exposed workers.

Original (SCP) IDLH for Cadmium fume: 9 mg Cd/m³

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that an exposure to 9 mg/m³ cadmium fume for 5 hours is a lethal dose [Beton et al. 1966]. AIHA [1962] reported that the lethal dose (single exposure) for man of thermally-generated cadmium oxide fume is not over 2,900 mg-min/m³ [Barrett and Card 1947] (mg-min/m³ is the product of the concentration in mg/m³ and the exposure time in minutes); this represents a concentration of about 50 mg/m³ for 1 hour. The concentration of 50 mg/m³ has not been chosen as the IDLH, however, because AIHA [1962] also reported that the doses which caused incapacitation must have been considerably lower [Barrett and Card 1947].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50	LCL0	Time	Adjusted 0.5-hr LC (CF)	Derived value
Cd: Rat	Yoshikawa and Homma 1974	25 mg/m3	-----	30 min	25 mg Cd/m3 (1.0)	2.5 mg Cd/m3
CdO: Rat Rabbit G. pig Dog Rat Mouse Rabbit G. pig Dog	Barrett et al. 1947 Barrett et al. 1947 Barrett et al. 1947 Barrett et al. 1947 Gates et al. 1946 Gates et al. 1946 Gates et al. 1946 Gates et al. 1946 Gekkan Yakuji 1980	500 mg/m3 2,500 mg/m3 3,500 mg/m3 4,000 mg/m3 780 mg/m3 340 mg/m3 3,000 mg/m3 3,000 mg/m3 400 mg/m3	---- ---- ---- ---- ---- ---- ---- ---- ----	10 min 10 min 10 min 10 min 10 min 10 min 15 min 15 min 10 min	304 mg Cd/m3 (0.69) 1,518 mg Cd/m3 (0.69) 2,125 mg Cd/m3 (0.69) 2,429 mg Cd/m3 (0.69) 473 mg Cd/m3 (0.69) 206 mg Cd/m3 (0.69) 2,086 mg Cd/m3 (0.79) 2,086 mg Cd/m3 (0.79) 243 mg Cd/m3 (0.69)	30 mg Cd/m3 152 mg Cd/m3 213 mg Cd/m3 243 mg Cd/m3 47 mg Cd/m3 21 mg Cd/m3 209 mg Cd/m3 209 mg Cd/m3 24 mg Cd/m3

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived Value
Cd: Rat Mouse	Kotsonis and Klaasen 1977 Tarasenko 1978	oral oral	225 890	----- -----	1,575 mg/m3 6,230 mg/m3	158 mg Cd/m3 623 mg Cd/m3
CdO: Rat Mouse	Gekkan 1980 Tarasenko 1978	oral oral	72 72	----- -----	444 mg/m3 444 mg/m3	44 mg Cd/m3 44 mg Cd/m3
CdCl2: Mouse Rat	Engstrom 1981 Lehman 1951	oral oral	60 88	----- -----	689 mg/m3 376 mg/m3	69 mg Cd/m3 38 mg Cd/m3

Other animal data: A rabbit 30-minute LC₅₀ of about 8,000 mg-min/m³ for cadmium dust has been reported [Friberg et al. 1974], which is equivalent to about 250 mg Cd/m³ for 30 minutes.

Human data: It has been reported that exposure to 9 mg/m³ of cadmium fume for 5 hours is a lethal dose [Beton et al. 1966]. Fatalities have resulted from exposures to concentrations estimated to be 40 to 50 mg/m³ for 1 hour [Barrett and Card 1947; Bulmer et al. 1938; Reinl 1961]. The lethal dose of thermally generated cadmium oxide fume of not more than 2,900 mg-min/m³ has been reported [Barrett and Card 1947], which is equivalent to about 85 mg Cd/m³ for 30 minutes. It has been reported that 39 mg Cd/m³ was a fatal exposure after 20 minutes [Zavon and Meadows 1970].

Revised IDLH: 9 mg Cd/m3 Basis for revised IDLH: Based on acute inhalation toxicity data in workers [Barrett and Card 1947; Beton et al. 1966; Bulmer et al. 1938; Reinl 1961; Zavon and Meadows 1970], the revised IDLH for cadmium compounds is 9 mg Cd/m3 which was the original IDLH for cadmium fume. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for cadmium compounds at any detectable concentration.]

 

REFERENCES:

1. ACGIH [1971]. Cadmium and compounds (as Cd). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 35-36.

2. AIHA [1962]. Cadmium (revised 1962). In: Hygienic guide series. Am Ind Hyg Assoc J 23:518-521.

3. Barrett HM, Card BY [1947]. Studies on the toxicity of inhaled cadmium. II. The acute lethal dose of cadmium oxide for man. J Ind Hyg Toxicol 29(5):286-293.

4. Barrett HM, Irwin DA, Semmons E [1947]. Studies on the toxicity of inhaled cadmium. I. The acute toxicity of cadmium oxide by inhalation. J Ind Hyg Toxicol 29(5):279-285.

5. Beton DC, Andrews GS, Davies HJ, Howells L, Smith GF [1966]. Acute cadmium fume poisoning: five cases with one death from renal necrosis. Br J Ind Med 23:292-301.

6. Bulmer FMR, Rothwell NF, Frankish ER [1938]. Industrial cadmium poisoning, a report of fifteen cases, including two deaths. Can J Public Health 29:19.

7. Engstrom B [1981]. Influence of chelating agents on toxicity and distribution of cadmium among proteins of mouse liver and kidney following oral or subcutaneous exposure. Acta Pharmacol Toxicol 48:108-117.

8. Friberg L, Piscator M, Nordberg GF, Kjellstrom T [1974]. Cadmium in the environment. 2nd ed. Cleveland, OH: CRC Press, p. 94.

9. Gates M, Williams J, Zapp JA [1946]. Arsenicals. In: Summary technical report of Division 9, NRDC. Vol. 1. Chemical warfare agents, and related chemical problems. Part 1. Washington, DC: Office of Scientific Research and Development, National Defense Research Committee, pp. 173-178.

10. Gekkan Yakuji (Pharmaceuticals Monthly) [1980]; 22:455-457 (in Japanese).

11. Kotsonis FN, Klaassen CD [1977]. Toxicity and distribution of cadmium administered to rats at sublethal doses. Toxicol Appl Pharmacol 41:667-680.

12. Lehman AJ [1951]. Chemicals in foods: a report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Q Bulletin Assoc Food Drug Off U.S. 15(4):122-125.

13. Reinl W [1961]. Arch Toxicol 19:1952. [From ACGIH [1991]. Cadmium and compounds. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 190-194. Cited by Teisinger et al. [1969] from Documentation of MAC in Czechoslovakia, Prague (1969).]

14. Tarasenko NY, ed. [1978]. Aktual’nye Problemy Gigieny Truda (Current Problems of Labor Hygiene) Moscow: Pervyi Moskovski Meditsinskii Institute, p. 14 (in Russian).

15. Yoshikawa H, Homma K [1974]. Toxicity of inhaled metallic cadmium fumes in rats. Sangyo Igaku (Japanese Journal of Industrial Health) 16:212-215 (in Japanese).

16. Zavon MR, Meadows CD [1970]. Vascular sequelae to cadmium fume exposure. Am Ind Hyg Assoc J 31(2):180-182.