Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)
CAS number: 72–20–8
NIOSH REL: 0.1 mg/m3 [skin] TWA
Current OSHA PEL: 0.1 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.1 mg/m3 TWA [skin]
Description of Substance: Colorless to tan, crystalline solid with a mild, chemical odor.
LEL:. . Noncombustible Solid
Original (SCP) IDLH*: 2,000 mg/m3 [*Note: "Effective" IDLH = 200 mg/m3 -- see discussion below.]
Basis for original (SCP) IDLH: Based on the statement by ACGIH  that 3 of 10 rats were reported to have died following a 1-hour exposure at about 2,000 mg/m3 [Anderson et al. 1953; Hine et al. 1954], an IDLH of 2,000 mg/m3 was chosen. Because of the assigned protection factor afforded by each device, however, 2,000 × the OSHA PEL of 0.1 mg/m3 (i.e., 200 mg/m3) is the concentration above which only the "most protective" respirators are permitted.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
|Rat||ACGIH 1971||LC30: 2,000 mg/m3||-----||1 hr||2,500 mg/m3 (1.25)||250 mg/m3|
Lethal dose data:
Ottolenghi et al. 1974
Sanderson and Noakes 1970
Treon et al. 1955
Treon et al. 1955
Webb et al. 1973
|21 mg/m3 |
|2.1 mg/m3 |
Human data: An oral dose of 171 mg/kg has been reported to be lethal [Runhaar et al. 1985]. It has also been reported that the approximate oral dose producing convulsions is about 0.2 mg/kg [Hayes 1982]. [Note: Oral doses of 171 mg/kg or 0.2 mg/kg are equivalent to a 70-kg worker being exposed to about 8,000 mg/m3 or 9 mg/m3, respectively, for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
|Revised IDLH: 2 mg/m3
Basis for revised IDLH: The revised IDLH for endrin is 2 mg/m3 based on acute oral toxicity data in humans [Hayes 1982] and animals [AAPCO 1966; Sanderson and Noakes 1970; Treon et al. 1955; Webb et al. 1973]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.
1. AAPCO . Pesticide chemicals official compendium. Association of the American Pesticide Control Officials, Inc., p. 475.
2. ACGIH . Endrin. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 98.
3. Anderson HH, et al. . Berkeley, CA: University of California, Report No. 213. [From ACGIH . Endrin. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 98.]
4. Hayes WH Jr . Pesticides studied in man. Baltimore, MD: Williams & Wilkins Company, pp. 247-251.
5. Hine CH, et al. . Berkeley, CA: University of California, Report No. 233. [From ACGIH . Endrin. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 98.]
6. Ottolenghi AD, Haseman JK, Suggs F . Teratogenic effects of aldrin, dieldrin, and endrin in hamsters and mice. Teratology 9:11-16.
7. Runhaar EA, Sangster B, Greve PA, Voortman M . A case of fatal endrin poisoning. Hum Toxicol 4:241-247.
8. Sanderson DM, Noakes DN . Acute toxicity data for pesticides (1970). World Review of Pesticide Control 9:119-127.
9. Treon JF, Cleveland FP, Cappel J . Toxicity of endrin for laboratory animals. J Agri Food Chem 3:842-848.
10. Webb RE, Hartgrove RW, Randolph WC, Petrella VJ, Horsfall
F Jr . Toxicity studies in endrin-susceptible and resistant
strains of pine mice. Toxicol Appl Pharmacol 25:42-47.
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