Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 71-23-8
NIOSH REL: 200 ppm (500 mg/m3) TWA, 250 ppm (625 mg/m3) STEL [skin]
Current OSHA PEL: 200 ppm (500 mg/m3) TWA
1989 OSHA PEL: 200 ppm (500 mg/m3) TWA, 250 ppm (625 mg/m3) STEL
1993-1994 ACGIH TLV: 200 ppm (492 mg/m3) TWA, 250 ppm (614 mg/m3) STEL [skin]
Description of substance: Colorless liquid with a mild, alcohol-like odor.
LEL: . . 2.2% (10% LEL, 2,200 ppm)
Original (SCP) IDLH: 4,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty  that 2 of 6 rats died following a 4-hour exposure to 4,000 ppm [Smyth et al. 1954]. In addition, Patty  reported that deep narcosis was produced in 2 mice exposed to 4,100 ppm for 4 hours [Starrek 1938].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Time||Adjusted 0.5-hr |
|Rat||Smyth et al. 1954||LC33: 4,000||-----||4 hr||8,000 ppm (2.0)||800 ppm|
Lethal dose data:
|Adjusted LD||Derived value|
|Rabbit||Munch & Schwartze 1925||oral||2,800||-----||7,840 ppm||784 ppm|
|Mouse||Savini 1968||oral||6,800||-----||19,040 ppm||1,904 ppm|
|Rat||Smyth et al. 1954||oral||1,870||-----||5,236 ppm||524 ppm|
Other animal data: RD50 (mouse), 12,704 ppm [Alarie 1981]. It has been reported that deep narcosis was produced in 2 mice exposed to 4,100 ppm for 4 hours [Starrek 1938].
Human data: Mild irritation of the eyes, nose, and throat have been reported at 400 ppm [Nelson et al. 1943]. It has been reported that 5,700 mg/kg is the lethal oral dose [Durwald and Degen 1956]. [Note: An oral dose of 5,700 mg/kg is equivalent to a 70-kg worker being exposed to about 94,000 ppm for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
|Revised IDLH: 800 ppm |
Basis for revised IDLH: The revised IDLH for n-propyl alcohol is 800 ppm based on acute inhalation toxicity data in humans [Nelson et al. 1943] and animals [Smyth et al. 1954]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 400 ppm.
1. Alarie Y . Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 42:9-13.
2. Durwald W, Degen W . Eine todliche vergiftung mit n-propyl alkohol. Arch Toxikol 16:85 (in German). [From ACGIH . n-Propyl alcohol. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1301-1302.]
3. Munch JC, Schwartze EW . Narcotic and toxic potency of aliphatic alcohols upon rabbits. J Lab Clin Med 10:985-996.
4. Nelson KW, Ege JF, Ross M, Woodman LE, Silverman L . Sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 25(7):282-285.
5. Patty FA, ed. . Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., pp. 1434-1435.
6. Savini EC . Estimation of the LD50 in mol/kg. Proc Eur Soc St Drug Tox 9:276-278.
7. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC . Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.
8. Starrek E . The effect of some alcohols, glycols, and esters. Doctoral dissertation (translated). Wurzburg, Germany: Julius Maximillian University.
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