Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Hexachloroethane

CAS number: 67–72–1

NIOSH REL: 1 ppm (10 mg/m3) TWA [skin]; NIOSH considers hexachloroethane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 1 ppm (10 mg/m3) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 1 ppm (9.7 mg/m3) TWA [skin], A2

Description of Substance: Colorless crystals with a camphor-like odor.

LEL:. . Noncombustible Solid

Original (SCP) IDLH: 300 ppm

Basis for original (SCP) IDLH: Based on the toxicological data relating to potential liver injury [Gleason et al. 1969; Elkins 1959], 300 ppm, the saturated vapor pressure at 20 C [Kirk-Othmer 1964] has been chosen as the IDLH.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
Rat

G. pig

Weeks et al. 1979

Weeks et al. 1979

oral

oral

4,460

4,970

-----

-----

3,173 ppm

3,536 ppm

317 ppm

354 ppm


Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 300 ppm [Unchanged]

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for hexachloroethane. Therefore, based on acute oral toxicity data in animals [Weeks et al. 1979], the original IDLH for hexachloroethane (300 ppm) is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for hexachloroethane at concentrations above 1 ppm.]


REFERENCES:

1. Elkins HB [1959]. Hexachloroethane, C2Cl6. In: The chemistry of industrial toxicology. 2nd ed. New York, NY: John B. Wiley & Sons, Inc., pp. 142-143.

2. Gleason MN, Gosselin RE, Hodge HC, Smith RP [1969]. Clinical toxicology of commercial products. 3rd ed. Baltimore, MD: Williams & Wilkins Company, pp. II-76, III-65 to III-67.

3. Kirk-Othmer [1964]. Encyclopedia of chemical technology. 2nd ed. New York, NY: John Wiley & Sons, Inc. 5:166.

4. Weeks MH, Angerhofer KA, Bishop R, et al. [1979]. The toxicity of hexachloroethane in laboratory animals. Am Ind Hyg Assoc J 40:187-199.

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO