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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


n-Amyl acetate

CAS number: 628-63-7

NIOSH REL: 100 ppm (525 mg/m3) TWA

Current OSHA PEL: 100 ppm (525 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 100 ppm (532 mg/m3) TWA

Description of substance: Colorless liquid with a persistent banana-like odor.

LEL: 1.1% (10% LEL, 1,100 ppm)

Original (SCP) IDLH: 4,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Browning [1965] that exposure to 4,000 ppm of a mixture of n-amyl acetate and isoamyl acetate produced complete loss of reflexes in rabbits within an hour [Koelsch 1912], and on the statement by Sax [1975] that 5,000 ppm n-amyl acetate produced deep narcosis in cats in 30 minutes.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:
  Adjusted  
  LC50 LCLo   0.5-hr Derived
Species Reference (ppm) (ppm) Time LC (CF) Value
Rat NPIRI 1974 ----- 5,200 ? ? ?

Lethal dose data:
  LD50 LDLo   Derived
Species Reference Route (Mg/kg) (mg/kg) Adjusted LD Value
Rabbit Marhold 1986 oral 7,400 ----- 9,575 ppm 958 ppm
Rat NPIRI 1974 oral 6,500 ----- 8,410 ppm 841 ppm

Other animal data: RD50 (mouse), 1,531 ppm [Alarie 1981].

Human data: Somnolence has been reported after exposure to 952 ppm for 30 minutes [Lehmann 1913].

Revised IDLH: 1,000 ppm

Basis for revised IDLH: The revised IDLH for n-amyl acetate is 1,000 ppm based on acute toxicity data in humans [Lehmann 1913] and animals [Alarie 1981; Marhold 1986].

References:

  1. Alarie Y [1981]. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 42:9-13.
  2. Browning E [1965]. Toxicity and metabolism of industrial solvents. New York, NY: Elsevier Publishing Company, p. 539.
  3. Koelsch [1912]. Damage to health by amyl acetate. Concordia No. 12.
  4. Lehmann KB [1913]. Experimentelle studien uber den einflufs technisch wichtiger gase und dampfe auf den organimus (XXXII/XXXIII). Amylazetat und cyclohexanolazetat. Arch Hyg 78:260-273 (in German).
  5. Marhold J [1986]. Prehled prumyslove toxikologie: organicke latky. Prague, Czechoslovakia: Avicenum, p. 357 (in Czechoslovakian).
  6. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 3.
  7. Sax NI [1975]. Dangerous properties of industrial materials. 4th ed. New York, NY: Van Nostrand Reinhold Company, Inc., p. 398.
 
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