Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
Share
Compartir
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


n-Propyl nitrate

CAS number 627-13-4

NIOSH REL 25 ppm (105 mg/m3) TWA, 40 ppm (170 mg/m3) STEL

Current OSHA PEL 25 ppm (110 mg/m3) TWA

1989 OSHA PEL 25 ppm (105 mg/m3) TWA, 40 ppm (170 mg/m3) STEL

1993-1994 ACGIH TLV 25 ppm (107 mg/m3) TWA, 40 ppm (172 mg/m3) STEL

Description of substance Colorless to straw-colored liquid with an ether-like odor.

LEL . . 2% (10% LEL, 2,000 ppm)

Original (SCP) IDLH 2,000 ppm

Basis for original (SCP) IDLH The chosen IDLH is based on the statement by ACGIH [1971] that the dog 4-hour LC50 is 2,000 to 2,500 ppm [Rinehart et al. 1958].

Short-term exposure guidelines None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 

SpeciesReferenceLC50

(ppm)

LCLo

(ppm)

TimeAdjusted 0.5-hr

LC (CF)

Derived value
RatHood 1953-----10,0004 hr20,000 ppm (2.0)2,000 ppm
RatRinehart et al Mouse. 1958 -----9,000 - 10,0004 hr18,000-20,000 ppm (2.0)1,800-2,000 ppm
MouseRinehart et al. 1958 -----6,000 - 7,0004 hr12,000-14,000 ppm (2.0)1,200-1,400 ppm
DogRinehart et al. 1958 -----2,000 - 2,5004 hr4,000- 5,000 ppm (2.0)400- 500 ppm

Human data None relevant for use in determining the revised IDLH.

 

Revised IDLH: 500 ppm

Basis for revised IDLH: The revised IDLH for n-propyl nitrate is 500 ppm based on acute inhalation toxicity data in animals [Rinehart et al. 1958].

REFERENCES:

1. ACGIH [1971]. n-Propyl nitrate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 217-218.

2. Hood DB [1953]. Toxicity of n-propyl nitrate and isopropyl nitrate. Report No. 21-53, Medical Research Project No. MR-170. Newark, DE: E.I. du Pont de Nemours & Co., Inc., Haskell Laboratory for Toxicology and Industrial Medicine.

3. Rinehart WE, Garbers RC, Greene EA, Stoufer RM [1958]. Studies on the toxicity of n-propyl nitrate vapor. Am Ind Hyg Assoc J 19:80-83.

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO