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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


n-Propyl nitrate

CAS number 627-13-4

NIOSH REL 25 ppm (105 mg/m3) TWA, 40 ppm (170 mg/m3) STEL

Current OSHA PEL 25 ppm (110 mg/m3) TWA

1989 OSHA PEL 25 ppm (105 mg/m3) TWA, 40 ppm (170 mg/m3) STEL

1993-1994 ACGIH TLV 25 ppm (107 mg/m3) TWA, 40 ppm (172 mg/m3) STEL

Description of substance Colorless to straw-colored liquid with an ether-like odor.

LEL . . 2% (10% LEL, 2,000 ppm)

Original (SCP) IDLH 2,000 ppm

Basis for original (SCP) IDLH The chosen IDLH is based on the statement by ACGIH [1971] that the dog 4-hour LC50 is 2,000 to 2,500 ppm [Rinehart et al. 1958].

Short-term exposure guidelines None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 

SpeciesReferenceLC50

(ppm)

LCLo

(ppm)

TimeAdjusted 0.5-hr

LC (CF)

Derived value
RatHood 1953-----10,0004 hr20,000 ppm (2.0)2,000 ppm
RatRinehart et al Mouse. 1958 -----9,000 - 10,0004 hr18,000-20,000 ppm (2.0)1,800-2,000 ppm
MouseRinehart et al. 1958 -----6,000 - 7,0004 hr12,000-14,000 ppm (2.0)1,200-1,400 ppm
DogRinehart et al. 1958 -----2,000 - 2,5004 hr4,000- 5,000 ppm (2.0)400- 500 ppm

Human data None relevant for use in determining the revised IDLH.

 

Revised IDLH: 500 ppm

Basis for revised IDLH: The revised IDLH for n-propyl nitrate is 500 ppm based on acute inhalation toxicity data in animals [Rinehart et al. 1958].

REFERENCES:

1. ACGIH [1971]. n-Propyl nitrate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 217-218.

2. Hood DB [1953]. Toxicity of n-propyl nitrate and isopropyl nitrate. Report No. 21-53, Medical Research Project No. MR-170. Newark, DE: E.I. du Pont de Nemours & Co., Inc., Haskell Laboratory for Toxicology and Industrial Medicine.

3. Rinehart WE, Garbers RC, Greene EA, Stoufer RM [1958]. Studies on the toxicity of n-propyl nitrate vapor. Am Ind Hyg Assoc J 19:80-83.

 
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