Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
Share
Compartir
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Strychnine

CAS number: 57–24–9

NIOSH REL: 0.15 mg/m3 TWA

Current OSHA PEL: 0.15 mg/m3 TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.15 mg/m3 TWA

Description of substance: Colorless to white, odorless, crystalline solid.

LEL :. . . Unknown

Original (SCP) IDLH: 3 mg/m3

Basis for original (SCP) IDLH: No data on acute inhalation toxicity are available on which to base the IDLH for strychnine. The chosen IDLH, therefore, has been estimated from the statement by Gleason et al. [1969] that 30 mg by the oral route is usually a threat to an adult's life [Witthaus 1911].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

 

SpeciesReferenceRouteLD50

(mg/kg)

LDLo

(mg/kg)

Adjusted LDDerived value
Rabbit

Dog

Cat

Mouse

Rat

Rat

Flury and Zernik 1935

Moraillon & Pinault 1978

Moraillon & Pinault 1978

Prasad et al. 1981

Spector 1956

Ward & Crabtree 1942

oral

oral

oral

oral

oral

oral

-----

0.5

0.5

2

16

2.35

0.6

-----

-----

-----

-----

-----

4.2 mg/m3

3.5 mg/m3

3.5 mg/m3

14 mg/m3

112 mg/m3

17 mg/m3

0.4 mg/m3

0.4 mg/m3

0.4 mg/m3

1.4 mg/m3

11 mg/m3

1.7 mg/m3

Human data: It has been reported that the probable lethal oral dose is 1.5 to 2 mg/kg [Gosselin et al. 1984]. [Note: An oral dose of 1.5 to 2 mg/kg is equivalent to a 70-kg worker being exposed to 70 to 93 mg/m3 for 30 minutes assuming a 50 liter per minute breathing rate and 100% absorption.]




 

Revised IDLH: 3 mg/m3 [Unchanged]

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for strychnine. However, based on acute oral toxicity data in humans [Gosselin et al. 1984], the original IDLH for strychnine (3 mg/m3) is not being revised at this time.

REFERENCES:

1. Flury F, Zernik F [1935]. Zusammenstellung der toxischen und letalen dosen für die gebräuchlichsten gifte und versuchstiere. Abder Hand Biol Arbeitsmethod 4:1289-1422 (in German).

2. Gleason MN, Gosselin RE, Hodge HC, Smith RP [1969]. Clinical toxicology of commercial products. 3rd ed. Baltimore, MD: Williams & Wilkins Company, pp. 214-217.

3. Gosselin RE, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Baltimore, MD: Williams and Wilkins Company, pp. III-375 to III-376.

4. Moraillon R, Pinault L [1978]. Diagnostic et traitement d'intoxications courantes des carnivores. Rec Med Vet 154(2):137-150 (in French).

5. Prasad CR, Patnaik GK, Gupta RC, Anand N, Dhawan BN [1981]. Central nervous system stimulant activity of N-_3-chromene-3-carbonyl)-4 iminopyridine (compound 69/224). Indian J Exp Biol 19:1075-1076.

6. Spector WS [1956]. Handbook to toxicology. Vol. 1. Philadelphia, PA: W.B. Saunders Company, p. 286.

7. Ward JC, Crabtree DG [1942]. Strychnine X. Comparative accuracies of stomach tube and intraperitoneal injection methods of bioassay. J Am Pharm Assoc, Scientific Edition 31:113-115.

8. Witthaus RA [1911]. Manual of toxicology. 2nd ed. New York, NY: William Wood and Company, p. 1029.

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO