Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Glycidol

CAS number: 556–52–5

NIOSH REL: 25 ppm (75 mg/m3) TWA

Current OSHA PEL: 50 ppm (150 mg/m3) TWA

1989 OSHA PEL: 25 ppm (75 mg/m3) TWA

1993-1994 ACGIH TLV: 25 ppm (76 mg/m3) TWA

Description of Substance: Colorless liquid.

LEL: . . Unknown

Original (SCP) IDLH: 500 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC50 of 450 ppm and the rat 8-hour LC50 of 580 ppm [Hine et al. 1956 cited by ACGIH 1971, and Patty 1963].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived

value

Mouse

Rat

Hine et al. 1956

Hine et al. 1956

450

580

-----

-----

4 hr

8 hr

900 ppm (2.0)

1,450 ppm (2.5)

90 ppm

145 ppm


Other animal data: It has been reported that rats exposed repeatedly to 400 ppm for 7 hours per day, 5 days a week for 10 weeks showed no evidence of cumulative toxicity, only very slight irritation of the eyes, and slight lacrimation and respiratory distress following the first few exposures [Hine et al. 1956].

Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 150 ppm

Basis for revised IDLH: The revised IDLH for glycidol is 150 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956].


REFERENCES:

1. ACGIH [1971]. Glycidol. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 121-122.

2. Hine CH, Kodama JS, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.

3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1635.

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO