2-Aminopyridine
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 504-29-0
NIOSH REL: 0.5 ppm (2 mg/m3) TWA
Current OSHA PEL: 0.5 ppm (2 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.5 ppm (1.9 mg/m3) TWA
Description of substanceL: White powder, leaflets, or crystals with a characteristic odor.
LEL: Unknown
Original (SCP) IDLH: 5 ppm
Basis for original (SCP) IDLH: Very little quantitative data are available on which to base an IDLH for 2-aminopyridine. The chosen IDLH is based on the statement by ACGIH [1971] that a 5-hour exposure to about 5 ppm produced headache, increased blood pressure, and nausea in a worker [Watrous and Schulz 1950].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
| LL50 | LCLo | Derived | ||||
|---|---|---|---|---|---|---|
| Species | Reference | Route | (mg/kg) | (mg/kg) | Adjusted LD | Value |
| Rat | Marhold 1986 | oral | 200 | ----- | 385 ppm | 39 ppm |
| Mouse | Verschueren 1983 | oral | 50 | ----- | 90 ppm | 9 ppm |
Human data: A 5-hour exposure to approximately 5 ppm caused severe headache, increased blood pressure, flushing of the extremities, and nausea [Watrous and Schulz 1950]
Revised IDLH: 5 ppm [Unchanged] Basis for revised IDLH: Based on acute inhalation toxicity data in humans [Watrous and Schulz 1950], the original IDLH for 2-aminopyridine (5 ppm) is not being revised at this time. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 5 ppm. |
References:
- ACGIH [1971]. 2-Aminopyridine. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 11.
- Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 838 (in Czechoslovakian).
- Verschueren K [1983]. Handbook of environmental data of organic chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold, Co., p. 192.
- Watrous RM, Schulz HN [1950]. Cyclohexylamine, p-chlornitrobenzene, 2-aminopyridine: toxic effects in industrial use. Ind Med Surg 19(7):317-320.