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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Ronnel

CAS number: 299–84–3

NIOSH REL: 10 mg/m3 TWA

Current OSHA PEL: 15 mg/m3 TWA

1989 OSHA PEL: 10 mg/m3 TWA

1993-1994 ACGIH TLV: 10 mg/m3 TWA

Description of substance: White to light-tan, crystalline solid.

LEL:. . Noncombustible Solid

Original (SCP) IDLH: 5,000 mg/m3

Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for ronnel. The chosen IDLH, therefore, has been estimated from the statement by ACGIH [1971] that the dog oral LD50 is greater than 500 mg/kg.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

 

SpeciesReferenceRouteLD50

(mg/kg)

LDLo

(mg/kg)

Adjusted LDDerived value
Mouse

Rabbit

G. pig

Dog

Rat

AAPCO 1966

AAPCO 1966

AAPCO 1966

Klimmer 1971

Gig Sanit 1990

oral

oral

oral

oral

oral

2,000

420

1,400

500

625

-----

-----

-----

-----

-----

7,000 mg/m3

2,940 mg/m3

9,800 mg/m3

3,500 mg/m3

4,375 mg/m3

700 mg/m3

294 mg/m3

980 mg/m3

350 mg/m3

438 mg/m3

Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 300 mg/m3

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for ronnel. Therefore, the revised IDLH for ronnel is 300 mg/m3 based on acute oral toxicity in animals [AAPCO 1966; Klimmer 1971]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCES:

1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 965.

2. ACGIH [1971]. Ronnel. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 222.

3. Klimmer OR [1971]. Pflanzenschutz-und schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen. 2nd ed. Hattingen, Germany: Hundt-Verlag, p. 26.

4. Gig Sanit [1990]. Long-term effects from transformation products of pesticides and surfactants; 45(6):14-17 (in Russian).

 
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