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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


Vinyl toluene

CAS number: 25013–15–4

NIOSH REL: 100 ppm (480 mg/m3) TWA

Current OSHA PEL: 100 ppm (480 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 50 ppm (242 mg/m3) TWA, 100 ppm (483 mg/m3) STEL

Description of substance: Colorless liquid with a strong, disagreeable odor.

LEL: . . 0.8% (10% LEL, 800 ppm)

Original (SCP) IDLH: 5,000 ppm

Basis for original (SCP) IDLH: Because no data on acute inhalation toxicity are available on which to base an IDLH for vinyl toluene, the chosen IDLH has been based on an analogy with styrene, which has an IDLH of 5,000 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

 

SpeciesReferenceLC50

(ppm)

LCLo

(ppm)

TimeAdjusted 0.5-hr

LC (CF)

Derived value
MouseKrynskaya et al. 1969 615-----4 hr1,230 ppm (2.0)123 ppm

Lethal dose data:

 

SpeciesReferenceRouteLD50

(mg/kg)

LDLo

(mg/kg)

Adjusted LDDerived value
Mouse

Rat

Krynskaya et al. 1969

Yang & Mackerer 1990

oral

oral

-----

-----

3,160

2,255

4,505 ppm

3,215 ppm

451 ppm

322 ppm

Other animal data: RD50 (mouse), 16.4 ppm [DeCeaurriz et al. 1981].

Human data: Although eye and nasal irritation have been noted, 400 ppm has been considered a safe concentration [ACGIH 1986].


 

Revised IDLH: 400 ppm

Basis for revised IDLH: The revised IDLH for vinyl toluene is 400 ppm based on acute inhalation toxicity data in humans [ACGIH 1986]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 400 ppm.

REFERENCES:

1. ACGIH [1986]. Vinyl toluene. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 275-276.

2. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett 9:137-143.

3. Krynskaya IL, Petrova LI, Guricheva ZG, Robachevskaya EG, Bukevich GM [1969]. Toxicity of vinyltoluene and its determination in air. Gig Sanit 34(7-9):334-339 (translated).

4. Yang JJ, Mackerer CR [1990]. Acute toxicologic testing of para-methylstyrene using rats and dogs. J Am Coll Toxicol, Part B 1:77 [Abstract].

 
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