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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


n-Butyl glycidyl ether

CAS number: 2426–08–6

NIOSH REL: 5.6 ppm (30 mg/m3) 15-minute CEILING

Current OSHA PEL: 50 ppm (270 mg/m3) TWA

1989 OSHA PEL: 25 ppm (135 mg/m3) TWA

1993-1994 ACGIH TLV: 25 ppm (133 mg/m3) TWA

Description of Substance: Colorless liquid with an irritating odor.

LEL: . . Unknown

Original (SCP) IDLH: 3,500 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that the mouse 4-hour LC50 was greater than 3,500 ppm [Hine et al. 1956].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived

value

Mouse

Rat

Hine et al. 1956

Hine et al. 1956

>3,500

1,030

-----

-----

4 hr

8 hr

>7,000 ppm (2.0)

2,575 ppm (2.5)

>700 ppm

258 ppm


Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
Mouse

Rat

Hine et al. 1956

Smyth et al. 1962

oral

oral

1,530

2,050

-----

-----

1,980 ppm

2,652 ppm

198 ppm

265 ppm


Human data: None relevant for use in determining the revised IDLH.

 

Revised IDLH: 250 ppm

Basis for revised IDLH: The revised IDLH for n-butyl glycidyl ether is 250 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.


REFERENCES:

1. ACGIH [1971]. n-Butyl glycidyl ether (BGE). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 33.

2. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.

 
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