Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
Share
Compartir
May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


N,N-Dimethylaniline

CAS number: 121–69–7

NIOSH REL: 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]

Current OSHA PEL: 5 ppm (25 mg/m3) TWA [skin]

1989 OSHA PEL: 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]

1993-1994 ACGIH TLV: 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]

Description of Substance: Pale yellow, oily liquid with an amine-like odor.

LEL:. . Unknown

Original (SCP) IDLH: 100 ppm

Basis for original (SCP) IDLH: No quantitative data on acute inhalation toxicity are available for dimethylaniline. Because the TLV for dimethylaniline is based on an analogy with aniline [ACGIH 1971], the chosen IDLH is also based on an analogy with aniline, which has an IDLH of 100 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived

value

Rat Slusar et al. 1972-----504 hr100 ppm (2.0)10 ppm

Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
RatSmyth et al. 1962oral1,410-----1,958 ppm196 ppm


Human data: N,N-Dimethylaniline has been reported to be quantitatively less toxic than aniline but produces a very similar effect -- notably, methemoglobinemia [Clayton and Clayton 1981]. It has been reported that 50 mg/kg is the lethal oral dose [Hall 1969]. [Note: An oral dose of 50 mg/kg is equivalent to a 70-kg worker being exposed to 2,333 mg/m3 (463 ppm) for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

 

Revised IDLH: 100 ppm [Unchanged]

Basis for revised IDLH: Based on an analogy with aniline [Clayton and Clayton 1981] which has an IDLH of 100 ppm and to acute oral toxicity data in humans [Hall 1969], the original IDLH for N,N-dimethylaniline (100 ppm) is not being revised for at this time.


REFERENCES:

1. ACGIH [1971]. Dimethylaniline (n-dimethylaniline). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 89.

2. Clayton GD, Clayton FE, eds. [1981]. Patty's industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York: John Wiley & Sons, Inc., pp. 2416-2454.

3. Hall R [1969]. Adhesives. Washington DC: National Clearinghouse for Poison Control Centers Bulletin, p. 5. Jan/Feb, 1969.

4. Slusar MP, Zvezday VI, Kolodub FA [1972]. Hygienic standardization of N,N-dimethylaniline in the air of industrial premises. Gig Sanit 37(4):35-37 (in Russian).

5. Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.

 
Contact Us:
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO