Immediately Dangerous to Life or Health Concentrations (IDLH)
Methyl Cellosolve® acetate
CAS number: 110–49–6
NIOSH REL: 0.1 ppm (0.5 mg/m3 TWA [skin]
Current OSHA PEL: 25 ppm (120 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 5 ppm (24 mg/m3) TWA [skin]
Description of substance: Colorless liquid with a mild, ether-like odor.
LEL: . . 1.7% (10% LEL, 1,700 ppm)
Original (SCP) IDLH: 4,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with methyl methacrylate which has an IDLH of 4,000 ppm.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
|Cat||Flury & Wirth 1933||-----||1,222||7 hr||2,933 ppm (2.4)||293 ppm|
|Rat||Smyth & Carpenter 1948||-----||7,000||4 hr||14,000 ppm (2.0)||1,400 ppm|
Lethal dose data:
|Adjusted LD||Derived value|
|Rat||Smyth & Carpenter 1948||oral||3,390||-----||4,833 ppm||483 ppm|
|G. pig||Smyth et al. 1941||oral||1,250||-----||1,782 ppm||178 ppm|
Human data: It has been stated that methyl Cellosolve®
acetate is slightly less toxic than methyl Cellosolve®
[Gosselin et al. 1984].
|Revised IDLH: 200 ppm
Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth and Carpenter 1948], a value of about 1,000 ppm would have been appropriate for methyl Cellosolve® acetate. However, the revised IDLH for methyl Cellosolve® acetate is 200 ppm based on being 2,000 times the current NIOSH REL of 0.1 ppm (2,000 is an assigned protection factor for respirators; only the most reliable respirators are recommended above 2,000 times the NIOSH REL).
1. Flury F, Wirth W . Zur toxikologie der lösungsmittel (Verschieden ester, aceton, methylalkohol). Arch Gewerbepath Gewerbehyg 5:1-90 (in German).
2. Gosselin RF, Smith RP, Hodge HC . Clinical toxicology of commercial products. 5th ed. Baltimore, MD: Williams & Wilkins Company, p. II-183.
3. Smyth HF Jr, Carpenter CP . Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 30:63-68.
4. Smyth HF Jr, Seaton J, Fischer L . The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol 23:259-268.
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