Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

Methyl Cellosolve® acetate

May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

CAS number: 110–49–6

NIOSH REL: 0.1 ppm (0.5 mg/m3 TWA [skin]

Current OSHA PEL: 25 ppm (120 mg/m3) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 5 ppm (24 mg/m3) TWA [skin]

Description of substance: Colorless liquid with a mild, ether-like odor.

LEL: . . 1.7% (10% LEL, 1,700 ppm)

Original (SCP) IDLH: 4,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with methyl methacrylate which has an IDLH of 4,000 ppm.

Short-term exposure guidelines: None developed


Lethalconcentration data:





TimeAdjusted 0.5-hr


Derived value
CatFlury & Wirth 1933-----1,2227 hr2,933 ppm (2.4)293 ppm
RatSmyth & Carpenter 1948-----7,0004 hr14,000 ppm (2.0)1,400 ppm

Lethal dose data:





Adjusted LDDerived value
RatSmyth & Carpenter 1948oral3,390-----4,833 ppm483 ppm
G. pigSmyth et al. 1941oral1,250-----1,782 ppm178 ppm

Human data: It has been stated that methyl Cellosolve® acetate is slightly less toxic than methyl Cellosolve® [Gosselin et al. 1984].

Revised IDLH: 200 ppm

Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth and Carpenter 1948], a value of about 1,000 ppm would have been appropriate for methyl Cellosolve® acetate. However, the revised IDLH for methyl Cellosolve® acetate is 200 ppm based on being 2,000 times the current NIOSH REL of 0.1 ppm (2,000 is an assigned protection factor for respirators; only the most reliable respirators are recommended above 2,000 times the NIOSH REL).


1. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel (Verschieden ester, aceton, methylalkohol). Arch Gewerbepath Gewerbehyg 5:1-90 (in German).

2. Gosselin RF, Smith RP, Hodge HC [1984]. Clinical toxicology of commercial products. 5th ed. Baltimore, MD: Williams & Wilkins Company, p. II-183.

3. Smyth HF Jr, Carpenter CP [1948]. Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 30:63-68.

4. Smyth HF Jr, Seaton J, Fischer L [1941]. The single dose toxicity of some glycols and derivatives. J Ind Hyg Toxicol 23:259-268.

Contact Us:
  • Page last reviewed: December 4, 2014
  • Page last updated: December 4, 2014 The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC-INFO