Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)

n-Propyl acetate

CAS number: 109–60–4

NIOSH REL: 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL

Current OSHA PEL: 200 ppm (840 mg/m3) TWA

1989 OSHA PEL: 200 ppm (840 mg/m3) TWA, 250 ppm (1,050 mg/m3) STEL

1993-1994 ACGIH TLV: 200 ppm (835 mg/m3) TWA, 250 ppm (1,040 mg/m3) STEL

Description of substance: Colorless liquid with a mild, fruity odor.

LEL(@100°F): 1.7% (10% LEL(@100°F), 1,700 ppm)

Original (SCP) IDLH: 8,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that a 4-hour exposure to 8,000 ppm was fatal to 4 of 6 rats [Smyth et al. 1954].

Short-term exposure guidelines: None developed


Lethal concentration data:






TimeAdjusted 0.5-hr


Derived value
CatFlury & Wirth 1933 -----8,9415 hr19,223 ppm (2.15)1,922 ppm
RatSmyth et al. 1969 LC67: 8,000-----4 hr16,000 ppm (2.0) 1,600 ppm

Lethal dose data:






Adjusted LDDerived value




Jenner et al. 1964

Jenner et al. 1964

Munch 1972

Smyth et al. 1969













15,433 ppm

13,671 ppm

10,936 ppm

14,329 ppm

1,543 ppm

1,367 ppm

1,094 ppm

1,433 ppm

Other animal data: It has been reported that based on acute inhalation studies, n-propyl acetate appears to be more toxic than isopropyl acetate and ethyl acetate but less toxic than n-butyl acetate [ACGIH 1991].

Human data: None relevant for use in determining the revised IDLH.


Revised IDLH: 1,700 ppm

Basis for revised IDLH: The revised IDLH for n-propyl acetate is 1,700 ppm based on acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth et al. 1969]. The revised IDLH is roughly the same as the revised IDLHs for ethyl acetate and n-butyl acetate and is also 10% of the lower explosive limit of 1.7% (which was determined at 100°F). This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.


1. ACGIH [1971]. n-Propyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 216.

2. ACGIH [1991]. n-Propyl acetate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 1300.

3. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel. (Verschieden ester, aceton, methylalkohol.) Arch Gewerbepath Gewerbehyg 5:1-90 (in German).

4. Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG [1964]. Food flavourings and compounds of related structure. I. Acute oral toxicity. Food Cosmet Toxicol 2:327-343.

5. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg 41:31-33.

6. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

7. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS [1969]. Range-finding toxicity data: list VII. Am Ind Hyg Assoc J 30(5):470-476.

Contact Us: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO