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May 1994
 

Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)


sec-Hexyl acetate

CAS number: 108–84–9

NIOSH REL: 50 ppm (300 mg/m3) TWA

Current OSHA PEL: 50 ppm (300 mg/m3) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 50 ppm (295 mg/m3) TWA

Description of Substance: Colorless liquid with a mild, pleasant, fruity odor.

LEL:. . Unknown

Original (SCP) IDLH: 4,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that 2 of 6 rats died from a 4-hour exposure to 4,000 ppm [Smyth et al. 1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

 


Species

Reference
LC50

(ppm)

LCLo

(ppm)


Time
Adjusted 0.5-hr

LC (CF)

Derived

value

Rat

Rat

Smyth et al. 1954

UCC 1966

LC33: 4,000

-----

-----

2,000

4 hr

4 hr

8,000 ppm (2.0)

4,000 ppm (2.0)

800 ppm

400 ppm


Lethal dose data:

 


Species

Reference

Route
LD50

(mg/kg)

LDLo

(mg/kg)


Adjusted LD

Derived value
RatUCC 1966oral6,160-----7,187 ppm719 ppm


Human data: Volunteers noted an unpleasant odor and irritation of the eyes and upper respiratory tract at 100 ppm [Silverman et al. 1946].

 

Revised IDLH: 500 ppm

Basis for revised IDLH: The revised IDLH for sec-hexyl acetate is 500 ppm based on acute inhalation toxicity data in humans [Silverman et al. 1946] and animals [Smyth et al. 1954; UCC 1966].


REFERENCES:

1. ACGIH [1971]. sec-Hexyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 127.

2. Silverman L, Schulte HF, First MW [1946]. Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.

3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

4. UCC [1966]. Toxicology studies: methyl amyl acetate. New York, NY: Union Carbide Corporation, Industrial Medicine and Toxicology Department (7/28/66).

 
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